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What is Breslow Thickness?

Breslow Thickness is a critical measurement used to determine the depth of invasion of a melanoma, the most serious type of skin cancer. It's measured from the top layer of the epidermis down to the deepest point of the tumor. Understanding this depth helps doctors assess the cancer's stage and guide treatment decisions. Curious about how this affects prognosis? Let's delve deeper.
Mary McMahon
Mary McMahon
Mary McMahon
Mary McMahon

Breslow thickness is a measure of the size of a melanoma growth expressed in terms of how deeply into the epidermis the growth has penetrated. The deeper the Breslow thickness, the greater the possibility of metastases and the worse the prognosis for the patient. This is one among several measures used in the assessment of patients with melanoma to develop an appropriate treatment plan.

When unusual skin growths are identified in a patient, the growths are removed and examined in a lab to determine whether they are malignant and to collect more information about them. In the case of a melanoma, the pathologist will measure the height of the tumor to determine the Breslow thickness, expressed in millimeters. If the tumor is less than 1 millimeter high, there is a 95 to 100% five-year survival rate for the patient, a very good prognosis. Cancers between 1 and 2 millimeters have a five-year survival rate of 80 to 96%, while growths over 2 millimeters and smaller than 4 millimeters high have a reduced survival rate, around 60 to 70%.

A pathologist determines the thickness of the melanoma through measurement and testing in the laboratory.
A pathologist determines the thickness of the melanoma through measurement and testing in the laboratory.

The biggest tumors, over 4 millimeters in height, come with an estimated 37 to 50% survival rate for the patient. A high Breslow thickness is an indicator for aggressive treatment to increase the patient's chances, paired with careful monitoring for any sign of metastases to allow doctors to address additional growths as soon as possible. Medical imaging studies may be recommended to look for growths in other areas of the body and the patient can receive aggressive chemotherapy and other treatments to address the melanoma.

The oncologist may base the patient's prognosis on the Breslow thickness.
The oncologist may base the patient's prognosis on the Breslow thickness.

Doctor Alexander Breslow is generally credited with recognizing the connection between the level of tumor invasion and the prognosis for the patient, during research conducted in the 1970s. Measurements of the thickness of melanoma growths are known as the Breslow thickness in honor of his research. Doctors may also use other terms to describe a melanoma, including Clark level, looking specifically at how many layers of skin have been penetrated by the cancer, and staging, referring to the aggressiveness of the cancer and the possibility for metastases.

After removal of a tumor with a high Breslow thickness, medical imaging studies are frequently used to check for additional growths.
After removal of a tumor with a high Breslow thickness, medical imaging studies are frequently used to check for additional growths.

A melanoma diagnosis can be frightening, especially when technical terms like Breslow thickness start getting thrown around. Patients are entitled to ask for clear, understandable descriptions of their medical conditions and to get information about treatment options, prognosis with different kinds of treatment, and what to expect from treatment so they can make informed choices and their options.

Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a TheHealthBoard researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Learn more...
Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a TheHealthBoard researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Learn more...

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    • A pathologist determines the thickness of the melanoma through measurement and testing in the laboratory.
      By: kasto
      A pathologist determines the thickness of the melanoma through measurement and testing in the laboratory.
    • The oncologist may base the patient's prognosis on the Breslow thickness.
      By: Photographee.eu
      The oncologist may base the patient's prognosis on the Breslow thickness.
    • After removal of a tumor with a high Breslow thickness, medical imaging studies are frequently used to check for additional growths.
      By: Trish23
      After removal of a tumor with a high Breslow thickness, medical imaging studies are frequently used to check for additional growths.
    • Cancers with a Breslow thickness between 1 and 2 millimeters have a five-year survival rate of 80 to 96%.
      By: Photographee.eu
      Cancers with a Breslow thickness between 1 and 2 millimeters have a five-year survival rate of 80 to 96%.