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What Is a Clotting Mechanism?

By Eugene P.
Updated Mar 03, 2024
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A clotting mechanism is the series of chemical processes that occur in the body and that lead to the formation of a clot. A clot is a collection of cells that seals and protects damaged areas of blood vessels while the body heals itself. Although a clot can form because there has been an injury, it also can form because of certain diseases or blood disorders. A clot is intended to stop bleeding and prevent infection as well as provide a safe area for healing to occur. After the area has been repaired, the clot dissolves back into the body.

When a blood vessel is damaged, the clotting mechanism begins when the walls of the vessel release certain unique proteins. These proteins send signals to a type of cell in the blood called a platelet. Platelets are created in the bone marrow and are the first cells to encounter the damaged area. They immediately converge on the injury and form a temporary barrier to seal the wound and stop the bleeding.

The next event to occur is the activation of the thrombin system. This is also called a clotting cascade. After this part of the blood clotting process begins, a series of chemical reactions occurs. Each reaction forms a new set of chemicals and proteins, which then react again. This cascade results in the formation of long strands of a substance called fibrin.

The fibrin moves to the area that the platelets have sealed. Strands of fibrin attach themselves over the platelets to strengthen and stabilize the clot. The combination of platelets and fibrin strands completes the formation of the clot, and the injury can begin to heal.

The clotting mechanism varies slightly depending on the type of blood vessel in which the process is occurring. In veins, the clots will be formed from more fibrin than platelets. In arteries, the clots are more platelets than fibrin.

Certain diseases can cause the clotting mechanism to malfunction. In these cases, a clot might form for no reason. The clot also might continue to amass platelets and fibrin until it is large enough to block the blood vessel.

Similarly, there are disorders such as hemophilia that interrupt the clotting mechanism and hinder the formation of clots. In a hemophiliac, the clotting pathway that forms fibrin is disrupted, and the clotting cascade is unable to begin. Without the fibrin to stabilize the temporary clot, the platelets are easily broken apart, and bleeding resumes.

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Discussion Comments
By wavy58 — On Oct 17, 2011

I have watched clots form on my skin. I usually squeeze pimples until they bleed, and I’m also accident prone.

When a pimple comes to a head, I take two cotton swabs and apply pressure to two sides of it until all the pus comes out. That is followed by a clear liquid, and then blood.

Once the blood surfaces, I have to blot the area with a tissue until it stops oozing. When the blood has become gooey and just sits there, I know the clot is forming.

I get scratches on my arms a lot from my new puppy, and sometimes, his sharp little teeth draw the blood out of me. By the time I have wiped the area with alcohol, the blood is already starting to clot. In a few hours, it dries out to form a scab.

By Perdido — On Oct 17, 2011

I am friends with a severe hemophiliac. She has to have clotting factor replacement therapy several times a week to prevent an emergency situation.

All of her life, she has bruised easily. Her joints are often swollen and painful. As a child, she couldn’t do fun things that other kids did because of her condition.

The therapy helps her live more of a normal life. She hates being dependent upon something external, because she wonders what would happen if she ever were unable to get her treatment for some reason. It’s the best option for her, though.

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