We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Gene Mapping?

Mary Elizabeth
By
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

A gene is a set of instructions for making a molecule given through a set of nucleotides in a molecule of DNA or RNA, with most of the DNA existing on the 23 pairs of chromosomes in the nucleus of each human cell. The bases of the nucleotides—which are adenine, cytosine, guanine, and thymine—define the information in the gene and the molecular product, often a protein.

Gene mapping refers to one of two different ways of definitively locating the gene on a chromosome. The first type of gene mapping is also called genetic mapping. Genetic mapping refers to the use of linkage analysis to determine how two genes on a chromosome relate in their positions. Physical mapping, the other type of gene mapping, locates genes by their absolute positions on a chromosome using any technique available. Once a gene is located, it can be cloned, its DNA sequence determined, and its molecular product studied.

The first report of mapping a gene to a human autosome was published in 1968 by Roger Donahue and associates. Using a linkage analysis, he was able to estimate the genetic distance of 2.5 map units between two loci or gene locations on chromosome 1. In 1971, chromosome banding techniques were developed, which opened the way for researchers to be able to identify more types of alterations, included insertions, deletions, and translocations, as well as mapping to position. In connection with this, restriction fragment length polymorphism (RFLP) analysis was developed and led by the early 1990s to the identification of a number of genes associated with disease in humans. A complementary technique, fluorescence in situ hybridization, developed about the same time, also contributed to the mapping efforts.

An example of this process in application is the work done with the gene for cystic fibrosis. The cystic fibrosis gene was mapped by linkage analysis in 1985. This paved the way for its cloning in 1989 by Francis Collins and his associates. This led to a better understanding of the cause of the disease.

The foundation of gene mapping also laid the foundation for the Human Genome Project. The idea of sequencing the entire human genome was explored in the 1980s, but was not universally thought to be feasible. Impetus from the U.S. Department of Energy along with the National Institutes of Health (NIH) helped foster the 1990 launch of the project. The technical achievements mentioned above contributed to the project’s momentum. The project was completed in 2003.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Link to Sources
Mary Elizabeth
By Mary Elizabeth , Writer
Passionate about reading, writing, and research, Mary Elizabeth is dedicated to correcting misinformation on the Internet. In addition to writing articles on art, literature, and music for The Health Board, Mary works as a teacher, composer, and author who has written books, study guides, and teaching materials. Mary has also created music composition content for Sibelius Software. She earned her B.A. from University of Chicago's writing program and an M.A. from the University of Vermont.

Discussion Comments

By wyzandrea — On Oct 21, 2015

Gene mapping is an important link in the study of genetics and pharmacokinetic study.

By PinkLady4 — On Jun 19, 2011

In addition to using genetic mapping to break the genetic code,there are other studies to determine how to conquer some diseases.

Telemeres are attached to the ends of all the chromosomes. They are protective bits of DNA. Dr. Elizabeth Blackburn, PhD has found links between shorter telomeres and risk for cardiovascular disease, diabetes, some cancers, depression, osteoarthritis, and osteoporosis.

Research continues to find out how telomeres are so important at the cellular stage to prevent stress, aging and chronic diseases.

By poppyseed — On Jun 18, 2011

You know it does seem that any day now we are going to be able to find the cures for such diseases as AIDS and cancer, and it is all because of the revelation of the mapping of human genes!

I truly believe with all of my heart that before my generation dies out (and I’m a thirty something) that we will see these cures. That is if we can quit fighting each other over silly things long enough to focus on the knowledge that could get us there.

It truly is a miracle and utterly amazing to me that we have been given such aptitude to discover these teeny, tiny, wonderful pieces of creation to study and learn from. What a blessing!

By oscar23 — On Jun 18, 2011

Wait, people were mapping genes back in the 1960s? I thought this was a very modern development. What was gene mapping like back then? I have to admit, whenever I think about it today I picture some very futuristic process, but perhaps I'm off? Does anybody know?

Mary Elizabeth

Mary Elizabeth

Writer

Passionate about reading, writing, and research, Mary Elizabeth is dedicated to correcting misinformation on the...
Learn more
The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.