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What is Glisodin®?

By Christine Hudson
Updated Mar 03, 2024
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Glisodin® is a commercially-marketed antioxidant derived from cantaloupe extract. It is used as a holistic treatment in arthritis, liver disorders and heart disease, though many studies have been inconclusive regarding its benefit. Many proponents also believe that it may help fight more serious diseases as well. This extract is said to work by increasing the body’s production of superoxide dismutase (SOD) which are important enzymes that protect cells from oxidation.

Most antioxidants are supposed to work by helping the body detoxify and prevent damage due to exposure to harmful elements. The idea behind the product is that its natural source helps the body adjust better than artificial antioxidants do. This product also uses gliadin, a wheat protein, as a way of protecting the SOD. When the SOD combines with acid in the stomach and is not protected, a chemical change occurs, which renders the enzyme ineffective. Gliadin was added to the supplement to prevent this deterioration process.

Glisodin® is marketed as the first effective oral SOD supplement. Many are interested in this supplement for its supposed anti-aging effects and general health benefits. Aside from the effects of harmful elements in the body, Glisodin® is believed to stop the effects of oxidation and the loss of collagen in the skin, as well as promote cell regeneration, allowing skin to look and feel young for a longer period of time.

As with many natural supplements, Glisodin® is not a substance approved or regulated by the US Food and Drug Administration. While studies have not conclusively pinpointed negative or long-term side effects, it is widely suggested that its use be monitored by a professional. Those who have serious health issues such as anxiety or who are on any medication may wish to speak with their doctors before using this supplement. Several studies indicate anti-depressants may have a higher risk of reaction to Glisodin® use.

Many argue that the nutritional supplement contains small amounts of effective ingredients as opposed to the amount one can get in cantaloupe. Others claim that although you can get more SOD with food, most of it passes through the body before it can make use of it. This is generally the justification given for the lower SOD content found in the supplement, and it is commonly advised that a person taking the supplement not go over the daily recommended amount.

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Discussion Comments
By Geneactiv — On Apr 07, 2015

The original French clinical research on GliSODin has used 250 mg twice daily as the effective dose. You might be best to buy the 250 mg capsule but be very wary of capsules which are simply the Extramel extract which is not GliSODin. These are not capable of upregulating the protective genes and therefore will not do what the GliSODin research has shown.

Check the label to be sure that the product you are using is the genuine French product, GliSODin and not the melon extracts or other products claiming to contain SOD or superoxide dismutase.

By Geneactiv — On Apr 07, 2015

GliSODin's clinical action is nutrigenomic. There are two papers published by Vouldoukis in 2004 which investigate its unique action in upregulating the genes which code for the primary antioxidant enzymes, Superoxide dismutase, Glutathione peroxidase and Catalase. This is supported by two clinical trials which demonstrate its beneficial effects in cardiovascular disease and the other in protecting DNA from the damaging effects of hyperbaric oxygen in deep sea divers.

The amount of gliadin in the product is 8.3 mg per capsule - one very tiny breadcrumb and this is an essential part of its mechanism. The gliadin has not been shown to adversely affect those who are gluten intolerant - in fact, it upregulates a compound in the intestine known as Interleukin-10 which is anti-inflammatory. This can actually benefit those with IBD and similar conditions.

By candyquilt — On Jan 29, 2013

I've heard that those with gluten intolerance or sensitivity may react badly to Glisodin. Has anyone experienced something like this?

I've also heard that once people stop taking Glisodin, all of its beneficial effects are lost. So taking it for a short time doesn't work. It's not a very affordable supplement so I don't know how anyone would go about taking it forever.

Glisodin is a supplement but that doesn't mean that it cannot have side effects. Of course, everyone does react a little differently to supplements and drugs. So Glisodin may work well for someone and not so much for someone else. But since supplements are not studied extensively as drugs are, it's better to be cautionary with the doses and ask the doc before using it in my opinion.

By discographer — On Jan 29, 2013

@ysmina-- I'm taking Glisodin Skin Nutrients (but you can take any Glisodin supplement) for rosacea. I started getting results after one month of taking 250 mg per day. The regular dose is actually 500 mg but 250 mg has been enough for me. I plan on taking it indefinitely.

By ysmina — On Jan 28, 2013

What dose of Glisodin should I use and for how long to take advantage of its anti-aging properties? I have Glisodin in 100 mg capsules.

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