We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Guaifenesin Phenylephrine?

By Mary Ellen Popolo
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Guaifenesin phenylephrine is a combination of two medications commonly found in many over-the-counter (OTC) cold and flu medications. Guaifenesin is an expectorant and works to loosen chest congestion. Phenylephrine is a decongestant and helps to relieve nasal stuffiness, sinus pressure and sinus congestion. These medications work together to relieve symptoms of the common cold and flu, including nasal congestion, coughs, runny nose, sneezing and sinus pressure.

Guaifenesin is an expectorant. Expectorants loosen and break up mucus in the chest, making it easier to expel it from your body; as a result, the air passageways are clearer and breathing becomes easier. Guaifenesin is also known as guaiphenesin and glyceryl guaiacolate. Guaifenesin is readily available over the counter in several name brands, as well as by prescription. It is sold as a single medication or in combination with other medications, such as phenylephrine or acetaminophen.

Phenylephrine is a decongestant. Decongestants work by shrinking the blood vessels in the nasal air passages. As a result, the nasal passages return to normal size and breathing becomes easier. Phenylephrine is also sold in nasal spray form.

Guaifenesin phenylephrine is taken orally and recommended for children and adults over 12 years of age. Some forms may be available for children between the ages of 6 and 12, though it is strongly advised to avoid giving any expectorants or decongestants to children under 6 years old. Pregnant and nursing moms should not take this medication, in any form, unless it is recommended by their physician. Guaifenesin phenylephrine should always be taken with a full glass of water and, if nausea is experienced while taking this medication, taking the medication after eating may help.

This medication combination is available in several forms, including tablets, capsules, time-release capsules, and liquid. Dosage depends on several factors, including the type and strength of the medication, and the age of the person taking it. Always follow package directions or your doctor’s instructions when taking this, or any, medication. Take only the recommended dosage and never take more than the directions advise. Follow the instructions for how often to take the medication and, if you miss a dose, skip it; do not take two doses at the next dose time.

Side effects of guaifenesin phenylephrine include nausea, dizziness and headaches. If you experience more serious side effects, such as fainting, shaking, seizures irregular heartbeat, trouble urinating, severe mood swings, or insomnia, consult with your physician immediately. Allergic reactions to guaifenesin phenylephrine are rare. Seek medical attention immediately if you suspect an allergic reaction. Symptoms of an allergic reaction include rash; itching; swelling of the mouth, throat and face; extreme dizziness; and difficulty breathing.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.