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What Is Ketoprofen Cream?

By Andy Josiah
Updated Mar 03, 2024
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Ketoprofen cream is just one of the forms of administration available for a drug that people use as an analgesic and antipyretic. This means that its role is to relieve pain and reduce fever, respectively. In a few countries, ketoprofen cream is referred to as Fastum. Ketoprofen's most popular form, however, is as a capsule, typically manufactured in 50-, 75- and 200-milligram doses. Other forms in addition to the cream and capsules include liquid spray and intravenous liquid.

Nonsteroidal anti-inflammatory drugs (NSAIDs) is the pharmaceutical category that ketoprofen cream is placed under. This is because in addition to its painkilling and antipyretic effects, it acts as an anti-inflammatory drug in larger doses. Its capabilities as an NSAID enables ketoprofen cream to be applied to several medical conditions. It is most commonly used, though, for rheumatoid arthritis, an inflammatory disorder that affects the joints, tissues and organs; and osteoarthritis, a degenerative disorder that involves breakdown of the lining of joints. Ketoprofen cream works by halting the body's production of prostaglandin, a lipid compound that causes pain, fever and inflammation.

Ketoprofen cream may cause side effects such as constipation, diarrhea, dizziness, drowsiness, insomnia, mouth sores or nervousness. It may also generate more serious signs such as fever, lack of energy, swelling, rashes or blisters, weight gain, vision or eye problems, increased heartbeat or weight gain. Occurrence of any of the latter side effects demands an immediate visit to the doctor.

In the United States, the Food and Drug Administration (FDA), the arm of the Department of Health and Human Services responsible for regulating the country's pharmaceuticals, approved ketoprofen on 22 December 1992. Ketoprofen goes by the Orudis and Oruvail brand names in the U.S. The FDA places Ketoprofen in the middling category C of its classification system of pharmaceutical risk to the fetus. This means that despite potential risk, pregnant women can use the medication since there is a lack of sufficient studies of the drug's effect on humans. Pregnant women in their third trimester, however, are more carefully monitored, as physicians believe they are at increased risk.

Ketoprofen cream is used in several other countries. The United Kingdom shares the Oruvail brand name with the U.S., and also uses Ketoflam. Other countries that have approved Ketoprofen include Croatia, Finland, France, Italy, Lithuania, Mexico, Russia, Serbia, Slovenia and Venezuela. The drug goes by many other brand names in these countries, including Arthril, Ketonal, Ketorin, Keto, Ketomex, Ketoprofenum, Knavon, Oki and Zon.

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Discussion Comments
By anon1005089 — On Jun 21, 2021

I am a formulation chemist developing a ketoprofen/ plant based topical lotion for my wife's RA afflicted knee joints.

I have been less than enthusiastic regarding current topical treatments intended for this ailment that affects a considerable percentage of the population.

Stay in contact due to the fact I am developing a double blind trial lotion based on the exact same formula and also contains peer reviewed plant based anti-inflammatory additives as well to significantly improve performance.

I am working with a major university in Texas to prove efficacy.

By anon938937 — On Mar 11, 2014

My mom uses this cream on her knees for her arthritis. Last year (2013) her insurance paid for half the cost. Now her doctor is telling us that the insurance will not pay any of it after filing the pre-authorization (2014). Doesn't seem fair.

By anon319395 — On Feb 12, 2013

Any danger in using this cream my doc ordered: ketoprofen, cyclobenzaprine, baclofen, lidocaine?

By anon285988 — On Aug 18, 2012

Yes, this has to be made at a compounding pharmacy. I am a CPhT, and we make it quite often, enough so that we premake it ahead of times. I have never used it, but every patient I've talked to swears by it!

By turquoise — On Aug 24, 2011

@alisha-- I heard that ketoprofen has to be compounded at a nearby center and made into a topical cream. If I get my doctor to prescribe this for me, will I have to have it compounded then? Isn't it sold over the counter in already cream form?

I just have student insurance and if your insurance doesn't cover the cream, I think mine might not either. I want to try this cream because I have heard so much about how well it works for pain.

I am suffering from tendinitis. I already had weak ankle tendons, then I made it worse by jogging everyday and now I have tendinitis. It's causing me constant pain, all the time. It's even hard for me to sit in lectures with this pain. I keep taking Aleve, but I don't think this is a good long-term solution.

Do you or anyone else here know about where I can purchase this cream or if I have to have it prescribed?

And has anyone used this for tendinitis? Does it help?


By burcinc — On Aug 23, 2011

Ketoprofen is nothing less than a lifesaver if you ask me. I have had arthritis for the past seven years and I discovered ketoprofen cream several years ago.

I actually started off with the tablets. But when I heard that it is also available in topical form, I requested my doctor to switch to that instead. I am already taking so many tablets for my arthritis right now. I'd rather not take any more and trouble my kidneys. Plus, with arthritis, the treatment goes on indefinitely because this condition and the pain goes on too.

I'm really happy that I made the switch. Ketoprofen cream works well, equally well as the tablets I think.

By discographer — On Aug 22, 2011

Ketoprofen works great for muscle soreness and pain. I'm an athlete and the ketoprofen cream works better for me than most other anti-inflammatory pain relieving creams.

The problem is that recently, my insurance has stopped paying for it and it is not affordable enough for me to pay out of my own pocket. So when the tube I have runs out, I don't know what I'm going to do. I don't want to take the tablets because the tablets are too harsh on my sensitive stomach.

I really wish that my insurance would start covering it again. They told me that it is not produced in large quantities and that it is a medication which requires a lot of processing. All of this has caused the price of the cream to go up and it looks like my insurance company won't become convinced about paying it anytime soon.

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