We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Is Phenazone?

By S. Berger
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Phenazone, also called phenazon, is an analgesic, a type of medication used to relieve pain. It also functions as an anti-inflammatory medication and an antipyretic, meaning that it can alleviate fevers. This medication is part of a class of drugs called non-steroidal anti-inflammatories (NSAIDs), which include more well-known compounds like ibuprofen and acetaminophen. Often available as a tablet for oral consumption in many countries, it is also found in Europe in the form of ear drops, usually combined with a local anesthetic like lidocaine to treat earaches.

Many NSAIDs have relatively short half-lives, a term describing the length of time taken to clear half of an ingested drug from the body. Usually, the half-life of an NSAID ranges from six to eight hours. Phenazone has a longer half-life of up to 12 hours, making it a potentially favorable treatment option for persistent, moderate pain.

Pain from migraines in particular is well-suited for treatment with phenazone. A study on patients with recurring migraines found that about half of these individuals had their pain significantly reduced two hours after taking 1000 milligrams (mg) of this medication. About one-quarter of the patients had their pain disappear entirely after using it. Migraines cannot always be treated easily with over-the-counter pain relievers, making this particular drug an effective treatment option.

The risks of phenazone are similar to the risks carried by other NSAIDs, and they can include stomachaches, nausea, and allergic reactions. Allergic reactions to this medication generally occur as a result of a more general allergy to a class of chemicals called pyrazolones that phenazone belongs to. Like some other NSAIDs, this drug can also cause damage to the liver. When taken in normal therapeutic doses, liver toxicity isn't usually a problem, but it becomes a risk if taken in high doses, over long periods of time, or when consuming alcohol frequently.

Phenazone may sometimes occur in preparations with other medications, such as theophylline. In elderly patients, there may be an interaction with these two medications, however, which can change the dosages needed. A study found that administering theophylline sped up the rate that some patients metabolized phenazone, making the pain reliever less effective and shorter-acting. Patients that were less healthy were more prone to this effect occurring. The increased metabolism of this medication seemed to be due to a drug interaction occurring in the liver, which could potentially occur with similar medications such as caffeine, as well.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Related Articles

Discussion Comments
By anon953266 — On May 25, 2014

If someone accidentally put Phenazone ear drops into eyes what will be happen to the eyes?

By ysmina — On Sep 26, 2013

I've used phenazone for migraines in the past. It certainly helped but when I took it on a regular basis, I would experience nausea and upset stomach. I know that stomach issues like ulcers are a risk with all NSAIDs. So I eventually switched to another migraine medication that was easier on my stomach because I have chronic migraines and need medication often.

But I have a friend who uses phenazone for migraines and doesn't experience upset stomach. So I think people with migraines should give this medication a try. Not everyone has a sensitive stomach like I do.

By SteamLouis — On Sep 25, 2013

@donasmrs-- As far as I know, propyphenazone is derived from phenazone. So they're both analgesics that work similarly. But propyphenazone has more negative side effect than phenazone. It's actually banned in some countries for this reason. It's not banned in the US, but it does require a prescription.

If I had to choose one, I would choose phenazone.

By donasmrs — On Sep 24, 2013

What is the difference between phenazone and propyphenazone?

I was getting a prescription filled for phenazone and the pharmacist wanted me to clarify if I wanted phenazone or propyphenazone.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.