We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Is X-Linked Ichthyosis?

Mary McMahon
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

X-linked ichthyosis is a rare genetic skin disorder seen in men. Patients with this condition develop rough scales, especially on their extremities, and may experience dry skin and irritation because of the scaling. Treatment focuses on softening and removing the scales and moisturizing the skin to keep the patient comfortable. Women act as carriers and usually do not experience any health problems, although sometimes they have difficulty in labor and delivery.

This genetic condition is referred to as “x-linked” because the genes involved are located on the X chromosome. In men, who only inherit one copy of this chromosome, any defective genes will be amplified, because there are no corresponding genes to cancel them out. The defective gene causes a deficiency in an enzyme, steroid sulfatas, which plays a role in breaking down and shedding old skin. Women with two copies of the gene usually produce enough of the enzyme that they shouldn't experience skin symptoms.

Signs of X-linked ichthyosis start to appear shortly after birth. Infants will develop crusty gray to brown scales and in some cases exhibit corneal opacity. As they grow, these scales can harden and cause increasing discomfort. Treatment options can include medications to soften and break up the scales, as well as topical creams for the skin. Some patients may experience fertility problems related to testicular involvement, and men with X-linked ichthyosis may want to consider a medical evaluation if they want to have children, so they can learn more about their fertility.

This skin condition should not cause any other medical problems, although it is possible for a patient to have unrelated congenital issues. Patients need to be careful about managing their skin but can usually engage in a wide range of activities, including physical exertion. Some may discover that certain fabrics are more comfortable than others, and may need to accommodate their X-linked ichthyosis by being selective about clothing purchases to keep skin irritation low.

A woman who knows she is a carrier of X-linked ichthyosis has a chance of passing it to her sons. She may have a son without the gene by passing on her healthy version, or her son could inherit the defective X chromosome. A man with the condition will have carrier daughters by passing on his X chromosome. Women who are carriers should make sure this is noted in their medical charts, as it can be relevant to their medical care.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Mary McMahon
By Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a The Health Board researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Discussion Comments
Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a...

Learn more
The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.