We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

Is It OK to Combine Lisinopril and Grapefruit?

By B. Chisholm
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

The combination of lisinopril and grapefruit may be used. While grapefruit juice may interact with other medications, it has not been reported to be a problem with lisinopril. If a person is unsure about whether or not their medications are interacting, either with each other, or with foods, they should speak to their doctor or pharmacist.

Lisinopril belongs to the class of drugs called ACE-inhibitors which lower the blood pressure. They work by blocking the enzyme called the Angiotensin Converting Enzyme (ACR), which reduces the effect of angiotensin 2 and causes widening of the blood vessels, thereby lowering blood pressure. They may also decrease the work load of the heart.

All medicines are metabolized in the body and excreted through a number of different processes involving many organs and systems. Each drug undergoes metabolism in different ways and is affected by different factors. One of the systems involved in metabolism is the Cytochrome P450 enzyme system. Many drugs and some foods or drinks, such as grapefruit juice, influence this system. Some may inhibit specific enzymes in the system, while others may induce them.

If an enzyme becomes inhibited, this may result in reduced breakdown of drugs normally metabolized by that enzyme, resulting in raised levels and a possible increase in both therapeutic effect and adverse effects. Conversely, induction of an enzyme may result in a quicker breakdown of drugs normally metabolized by that enzyme, negating or lessening its required effect. Grapefruit juice is known to inhibit some of the enzymes involved in this system.

While lisinopril and grapefruit probably don't interact and can be used together, many other medications may interact with grapefruit juice due to its inhibitory action and it should be avoided by people taking them. Lisinopril and grapefruit don't fall within this group of medicines because lisinopril's metabolism does not rely on the enzymes which are blocked by grapefruit juice.

Drugs that may interact with grapefruit juice include some cholesterol drugs like statins such as atorvastatin; some calcium channel blockers, used for blood pressure and heart conditions which include felodipine and nicardipine; and some antiretroviral drugs, for people with HIV, such as saquinavir. This is by no means a full list of the medications which should not be taken with grapefruit juice. So, while there is probably no interaction between lisinopril and grapefruit, it may likely interact with other medications taken, including complementary, homeopathic and over-the counter preparations. Advice should be obtained from a doctor or pharmacist as to whether grapefruit juice should be avoided when taking some medications.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
By candyquilt — On Jul 04, 2013

@simrin-- I think your doctor is just being on the safe side. As far as I know, there is no proven interaction between lisinopril and grapefruit. But since grapefruit has been found to affect many medications, some physicians prefer that their patients not mix it with lisinopril just in case.

I think everyone should follow the advice of their physician. Our doctors know us better than strangers on the internet.

I'm on a very low dose of lisinopril and my doctor said that I can have grapefruit. I'm not a huge fan of grapefruit anyway so I have it occasionally. If my doctor told me not to eat it, I wouldn't eat it.

By SteamLouis — On Jul 04, 2013

I asked my doctor about this and he said that I should wait a few hours after I take my medication to eat grapefruit.

Does this mean that there might be an interaction between lisinopril and grapefruit?

By literally45 — On Jul 03, 2013

I'm so glad to know that grapefruit is okay to have while on lisinopril.

My sister is on beta-blockers for high blood pressure and she's not allowed to have any grapefruit. It prevents her medications from working and increases her blood pressure.

I thought that the same would be true for lisinopril but apparently not. I love grapefruit juice in the morning so I'm glad that I don't have to give it up.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.