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What are the Dangers of Large Platelets?

Mary McMahon
Updated Mar 03, 2024
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The dangers of large platelets vary, depending on the underlying cause for the increase in platelet size. In some patients, they may not cause any symptoms or problems, while others may develop bleeding disorders and other medical issues. Because an array of conditions can be responsible for an increase in platelet size, it may be necessary to conduct several different medical tests to find out why a patient has large platelets.

Macrothrombocytopenia, as it is formally known, occurs when the normally small and highly fragmented platelets are bigger than usual. Many people who have large platelets also have a reduced platelet count. The platelet size can be genetic, as seen in people with Bernard-Soulier syndrome, gray platelet syndrome, and May-Hegglin anomaly. In other cases, it may occur in response to problems in the bone marrow, such as cancers that disrupt the production of blood cells.

The most common problem experienced by people with large platelets is increased bleeding. The oversized platelets cannot clot properly and as a result, the patient may bleed freely from even small injuries, develop substantial bruising, and experience internal bleeding that is difficult to stop because the blood does not clot. This can become very dangerous if the bleeding is excessive and when it occurs internally, the patient may not be aware of it until substantial blood loss has occurred.

There can also be risks associated with the underlying disorder that is causing the large platelets to develop in the body. Progressive diseases involving the bone marrow can become fatal, and some genetic bleeding disorders are associated with issues ranging from hearing loss to joint deformations. Knowing the cause for the variation in platelet size will help a doctor identify additional risks for the patient, in addition to developing a treatment plan.

For genetic disorders, a cure is not possible. These disorders are usually diagnosed in childhood when parents notice that their children have signs of a bleeding disorder. Techniques to manage such disorders can include medications, transfusions of blood, and lifestyle adjustments. People with bleeding disorders need to be careful about exposure to injuries, and it is important to make sure that the condition is noted in patient charts so that care providers are aware of it. In cases where the cause is something that can be treated, resolving the cause should compel the platelets to return to a more conventional size, and the patient's clotting problems should come to an end.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Mary McMahon
By Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a The Health Board researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Discussion Comments

By anon959481 — On Jul 05, 2014

I have been told that I have an elevated blood count 4.58 first blood test rising to 4.73 2 weeks later. I am due to have another blood test next week, two and a half months later. If this shows further elevation, could this mean that I may have a serious illness?

By anon344892 — On Aug 13, 2013

I have been told I have large, sticky platelets. I don't bleed or bruise easily, lab counts don't work unless done instantly upon withdrawal, blood clotting at a wound is not a problem. I am not aware of any treatments for reducing "stickiness" or "size" of platelets.

By anon338201 — On Jun 12, 2013

The function of platelets is to help stopping blood when a person gets cut. These are colorless cells and stick together to stop the blood flowing out of blood veins.

By anon306979 — On Dec 02, 2012

My ex said he's got large platelets and an ectopic heat, but he's not on any meds and he said he could die from a serious attack any time. I don't believe him, but I can't stop worrying how this would affect him and what meds he should be on.

By anon303023 — On Nov 12, 2012

What are low platelets? What is the cause? What is the possible treatment?

By topher — On Apr 22, 2011

They help to clot the blood, so a low platelet count causes excessive bleeding, but a high count causes excessive clotting.

By ForMiles — On Apr 19, 2011

Perhaps this is a silly question, but what is the function of platelets?

Mary McMahon

Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a...

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