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What Is Factor VIII Deficiency?

Niki Acker
Updated Mar 03, 2024
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Factor VIII deficiency is a blood disorder characterized by insufficient or poorly functioning factor VIII, one of the blood clotting factors, also known as anti-hemophilic factor (AHF). Factor VIII deficiency is the cause of hemophilia A, a disease in which the blood does not clot well after injury, causing symptoms such as serious bleeding and frequent bruising. Factor VIII is expressed by the F8 gene on the X chromosome and is a recessive X-linked trait. It only affects males, or females who inherit the defective F8 gene from both their parents. Women are much more often asymptomatic carriers of the genetic defect.

Factor VIII deficiency is the most common cause of hemophilia. It results in the formation of blood clots with insufficient amounts of the protein fibrin, leading to weak and slow forming clots. About one in every 5,000 men suffers from Factor VIII deficiency, and 30% have no family history, suggesting recently mutated genes. Different types of mutations in F8 lead to different types of Factor VIII deficiency, and hemophilia A varies in severity depending upon how much Factor VIII is present in the patient.

Symptoms include internal and external bleeding episodes, especially after trauma. Patients with more severe forms of the disease may experience excessive bleeding as a result of minor injury. Bleeding into joints can lead to chronic symptoms including pain, impaired movement, and even disfigurement. Hemophilia A is often diagnosed early in life, for example when a newborn develops severe bruises or intercranial hemorrhage as a result of forceps or vacuum delivery. Excessive bleeding during a routine blood test or a circumcision can also be the first manifestation of the disease.

Hemophilia A is treated with intravenous transfusions of Factor VIII, either as needed, or as a preventative measure depending upon the severity of the disease and the particular needs of the patient. The disease may also be treated with desmopressin, which releases Factor VIII stored in the walls of the patient's blood vessels. In some cases, the patient develops inhibitory antibodies to the Factor VIII delivered through transfusions. Transfusions of Factor VII are sometimes helpful in such cases.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Niki Acker
By Niki Acker , Writer
"In addition to her role as a The Health Board editor, Niki Foster is passionate about educating herself on a wide range of interesting and unusual topics to gather ideas for her own articles. A graduate of UCLA with a double major in Linguistics and Anthropology, Niki's diverse academic background and curiosity make her well-suited to create engaging content for WiseGeekreaders. "

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Niki Acker

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