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What is Fructose Intolerance?

Hillary Flynn
Updated Mar 03, 2024
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The term fructose intolerance is used to refer to both hereditary fructose intolerance as well as fructose malabsorption. Hereditary fructose intolerance results in an inability of the body to digest fructose, because the appropriate liver enzymes are not able to break down fruit sugar. Fructose malabsorption was previously incorrectly referred to as fructose intolerance, but it is not the same condition. Fructose malabsorption refers to a condition in which intestinal cells needed to absorb the fructose are deficient.

Hereditary fructose intolerance occurs when the enzyme fructose-1-phosphate aldolase activity is deficient. Since it cannot be properly digested, fructose builds up in the liver, kidney, and small intestine. People suffering from this condition may experience abdominal pain, vomiting, nausea, excessive sweating, and hypoglycemia when fructose is ingested. Fructose is a sugar found in fruits, and those with an intolerance will also have issues digesting regular white sugar, brown sugar, and sorbitol.

Though elimination of foods sweetened with fructose or other sugars will prevent symptoms in most older children and adults, this condition can be life threatening for infants and the elderly. If left undiagnosed, sufferers may experience liver or kidney damage. Since many baby foods contain fructose, it is especially important to watch for signs and symptoms in infants.

Fructose malaborption differs from hereditary fructose intolerance in that those with the condition have no issues with intolerance, but rather the issue is with the absorption step that should occur in the intestine. Unabsorbed fructose builds up in the intestine when the intestinal cells responsible for absorption are not functioning. Instead, bacteria in the lower intestine must metabolize the fructose which produces hydrogen and/or methane gas. This causes gas, bloating, and diarrhea that can last from several hours to several days.

Another symptom of fructose malabsorption occurs a few days after fructose is ingested. The fructose built up in the lower intestine may bond with tryptophan, so that it is also prevented from being absorbed. Tryptophan is an amino acid that produces melotonin and serotonin. Melotonin helps regulate sleep, and serotonin is associated with mood. The lack of these neurotransmitters can cause sleep issues, difficulty concentrating, fatigue, irritability, anxiety, and depression.

To treat malabsorption, fructose must first be completely eliminated from the diet. Then, after a month or so, small portions of foods containing fructose may be added back into the diet. Each person will have a different reaction to the amount of fructose that is ingested, so one must gauge how much fructose can be allowed in the diet before symptoms will return.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Hillary Flynn
By Hillary Flynn , Writer
Hillary Flynn's insatiable curiosity led her to join the The Health Board team, where she contributes well-researched articles on various topics. In addition to her work with The Health Board, Hillary manages an electronic publishing business that allows her to develop her skills in technical writing, graphic design, and business development. With a passion for satirical writing and traveling to historical places, Hillary brings a distinctive voice to her content.

Discussion Comments

By anon73802 — On Mar 29, 2010

this is me in a nutshell. Four years being sick and I have panic attacks constantly. right now I'm trying to increase my serotonin levels naturally. Nausea/anxiety/insomnia/IBS. fun stuff.

Just tried antidepressants but they just made me more sick.

Hillary Flynn

Hillary Flynn


Hillary Flynn's insatiable curiosity led her to join the The Health Board team, where she contributes well-researched...
Learn more
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