We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Histamine?

Niki Foster
Updated Mar 03, 2024
Our promise to you
TheHealthBoard is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At TheHealthBoard, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Histamine is a chemical produced by the body that aids in immune response and acts as a neurotransmitter. In response to foreign pathogens in the body, this chemical is produced by basophils, a type of white blood cell, and mast cells, cells in the connective tissue with similar characteristics to basophils. Histamine helps fight off infection by making capillaries more permeable to white blood cells that fight pathogens.

Four types of histamine receptors, which interact with released histamine to produce a reaction, have been discovered in the body. H1 receptors are found on the smooth muscle tissue of the internal organs, the endothelium lining blood vessels, and central nervous system tissue. The interaction of histamine with these receptors is responsible for hives, itching and swelling due to insect bites and similar allergic reactions, and allergic rhinitis, or cold-like symptoms due to allergic reaction. H2 receptors are located on the parietal cells on the stomach lining and stimulate the secretion of gastric acid when activated; this process is a normal part of biological function and not a response to pathogens.

H3 receptors are located in the tissue of the central and parietal nervous system and are responsible for the decreased release of neurotransmitters including acetylcholine, histamine, norepinephrine, and serotonin. H4 receptors are located in the basophils, bone marrow, thymus, small intestine, spleen, and colon. They play a role in chemotaxis, the movement of body cells in reaction to a chemical in their environment.

In addition to its role in immune response, histamine helps regulate a number of processes in the body. It aids in the digestive function of the stomach, as mentioned above, and helps produce an orgasm through mast cells in the genitals. Histamine also helps regulate sleep, as the body produces more upon waking and less as the sleep cycle proceeds. For this reason, antihistamines can help a person fall asleep by limiting the chemical's release.

TheHealthBoard is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Niki Foster
By Niki Foster , Writer

In addition to her role as a TheHealthBoard editor, Niki enjoys educating herself about interesting and unusual topics in order to get ideas for her own articles. She is a graduate of UCLA, where she majored in Linguistics and Anthropology.

Discussion Comments

By bestcity — On Apr 16, 2009

Histamine is also a major cause of asthma.

Studies are being done on a protein of cells that release histamine. Potentially the protein will slow down the release of histamine, and hopefully avoid allergic reactions and asthma attacks.

Niki Foster

Niki Foster


In addition to her role as a TheHealthBoard editor, Niki enjoys educating herself about interesting and unusual...

Read more
TheHealthBoard, in your inbox

Our latest articles, guides, and more, delivered daily.

TheHealthBoard, in your inbox

Our latest articles, guides, and more, delivered daily.