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What is Mesterolone?

By Vicki Watson
Updated Mar 03, 2024
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Mesterolone is an oral anabolic steroid, a synthetic product of the male hormone testosterone. The drug has shown value in treating men with mental health issues, such as depression, anxiety and bipolar disorders. The drug also is commonly used to treat sexual dysfunction, including low sperm count. Additionally, mesterolone may enhance the effectiveness of other steroids. Interestingly, unlike other steroids, the drug shows little value for bodybuilding, but has the same health risks involved in steroid use for that purpose.

Mesterolone is often used as an antiestrogenic treatment and may be used by those who have had a poor reaction to testosterone treatments. The drug has shown to be beneficial in treating sexual dysfunction, impotency and low libido. Mesterolone binds to estrogen receptors, reducing their activity, which not only reduces estrogen production, but also encourages natural testosterone production in the body.

During the late 1970s, doctors who performed studies on mesterolone concluded that the drug could be used to treat depression in some men. Patients with symptoms of anxiety and low sex drive reported improvement with low doses of the steroid. During the study, higher doses proved helpful to patients with dysthymia and bipolar depression as well. Since this time, newer studies have shown that patients taking a placebo improved at the same rate as patients taking mesterolone, leading medical professionals to believe that better drug options exist.

One of the main benefits of mesterolone appears to be its ability to boost the effectiveness of other steroids. The drug's ability to disrupt estrogen production and increase testosterone in a man’s body allows other steroids to perform better. Additionally, mesterolone is a lipolytic drug, which helps the body burn fat faster.

Those taking mesterolone, however, run the risk of accelerating the growth of many cancers. For instance, those with prostate cancer, breast cancer or liver tumors should not take the steroid. Other risks involved include liver damage; hypercalcemia, or too much calcium in the blood; and increased cholesterol levels.

Mesterolone has not been shown to produce very impressive results in most studies of the drug. At best, it may assist other drugs serving functions that are more useful. Users should be aware that using steroids of any kind has the potential of doing significant damage to the body, including damage to major organs, such as the heart and liver. These damages may not manifest until years after the use of the product has stopped.

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Discussion Comments
By fify — On Jan 29, 2012

@feruze-- I happen to believe that there is no such thing as a safe steroid. The article did a great job of mentioning that the damage caused by steroid use is not diagnosed until many years after.

I've also seen studies about mesterolone and quite a few of them state that "no kidney damage" was found following these studies. I think this is really funny. Of course, there will be no apparent damage so soon after the use of a steroid. A lot more time needs to pass and these studies need to get back in touch with the participants and test them again for any damage.

I think all steroids, including mesterolone, should be used with utmost caution. In fact, they shouldn't be used unless it's completely necessary. I understand that you were trying to treat a medical condition which is fine. But using steroids simply for libido function or to aid in body building is just way too risky in my opinion.

By bear78 — On Jan 29, 2012

@turkay1-- Which brand name were you using?

I used Proviron mesterolone when I was living in Europe. My doctor told me about a study that was done on mesterolone and sperm count in 250 men. After these men who had low sperm levels received a mesterolone treatment, 150 of them were able to impregnate their partner. That's almost half of the people who participated!

My wife and I had been trying to conceive for several years and I was told to have very little sperm count. So I decided to give mesterolone a try even though I'm very wary about the use of steroids in general. We did get good results and my wife was pregnant two months later with our daughter.

I did have a bad side effect from mesterolone though. I experienced a lot of hair loss. I was expecting some baldness in the future, but mesterolone seemed to trigger it and bring it on very suddenly and much earlier than I wished for.

So there is a bad side to using this for libido and sperm count.

By candyquilt — On Jan 28, 2012

I've taken mesterolone along with other bodybuilding steroids in small doses to help improve their function. I honestly don't know if it helped me build muscle as I didn't notice any significant changes from when I only used the other steroids. But I did see a huge improvement in my libido.

Just 50mg did a lot for my libido and sexual performance. I was not aiming for this and definitely didn't expect it but I think mesterolone can be a good treatment for men experiencing low libido.

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