Fact Checked

What are the Most Common Estradiol Side Effects?

Tricia Christensen
Tricia Christensen
Tricia Christensen
Tricia Christensen

Estradiol is a medication that contains a form of the hormone estrogen. This is a very powerful hormone, and using topical or oral forms can cause serious side effects, including an increased risk of heart attack, blood clots, endometrial cancer, and breast cancer. Other estradiol side effects include headache, nausea, heartburn, and mood changes. Children should never be exposed to estradiol unless it is prescribed by a medical professional, and care should be taken when topical forms are used to avoid accidentally getting the medication onto other people.

People may use topical or oral forms of estradiol to treat some symptoms associated with the loss of estrogen due to menopause or as a hormonal replacement when the ovaries stop working or are removed. It may also help protect women against osteoporosis. A less common use is during end stage prostate cancer in men or to relieve some symptoms of breast cancer. It is available at various concentrations in tablet form, as a transdermal patch, as a cream, and as a topical spray.

Side effects of estradiol may include heartburn.
Side effects of estradiol may include heartburn.

Most of the guidelines for use of this medication suggest it be used for shortest possible time periods to reduce the chances of developing many of the more serious estradiol side effects. Using this hormone increases the risk of heart attack, stroke, deep vein thrombosis, and blood clots in some women, especially if they smoke or have a history of any of these conditions. When used as a hormone replacement, estradiol is sometimes combined with progestin; studies have shown that this combination can increase a woman's risk of breast cancer.

Women who use estradiol may notice breast growth and tenderness.
Women who use estradiol may notice breast growth and tenderness.

Headache is one of the more common estradiol side effects and may affect up to 20% of people who take it. Other side effects include dizziness, confusion, and problems speaking. Mood changes, including depression and anxiety, can also occur. Because this hormone can affect the cardiovascular system, any chest pain, numbness or weakness on one side of the body, or difficulty breathing could be a sign of a heart attack or stoke. These symptoms should be reported to a healthcare professional immediately.

Nausea and stomach pain are common side effects of estradiol.
Nausea and stomach pain are common side effects of estradiol.

This hormone, which acts to spur the growth of the female reproductive organs, can cause breast tenderness or pain, as well as increase breast growth in some people. It is often used to relieve vaginal dryness and inflammation, but it may also cause itching and discharge. Some women experience spotting in between periods and other unusual vaginal bleeding and changes in their menstrual cycles. It also increases the risk of yeast infections.

Side effects of estradiol may include hair loss.
Side effects of estradiol may include hair loss.

People who use topical estradiol may experience redness or irritation where the medication is applied. Flu-like symptoms, arthritic pain, and hair loss are all relatively common. Many people also report problems with their digestive systems, including stomach pain, nausea, vomiting, and bloating.

Certain populations should note a few other estradiol side effects. People who have diabetes and take this medication should monitor blood sugar levels carefully, as these may change. Those who have thyroid disorder should also watch their thyroid levels carefully. Even in people without hypothyroidism, long-term use of estradiol may reduce thyroid hormone levels to below normal readings.

Headaches are a common side effect of estradiol.
Headaches are a common side effect of estradiol.

Men and children should not be exposed to estradiol in most cases, as it can cause breast development. Girls who touch this medication may begin puberty prematurely. Pregnant woman should not take estradiol because it can increase a child's risk of developing abnormalities in the urinary and genital systems, as well as certain cancers later in life. It is not clear if this medication is passed to a child through breast milk, so women who are breastfeeding should speak to a medical professional before using it.

Breast tenderness is a common side effect of estradiol.
Breast tenderness is a common side effect of estradiol.

There is also some concern about the potential for estradiol to cause dementia, as it has been noted in some older patients who use it. In general, women who are well over menopause are discouraged from using this medication, especially on a long-term basis.

Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent TheHealthBoard contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent TheHealthBoard contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

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Discussion Comments


There is a product on Amazon in cream form I use with the least side effects compared to other pharmaceuticals. It's bio identical with all three hormones made by some Gyno in Florida its called Hormone Heaven or Young Hormones. I've been very impressed by the product after 15 years of trial and error.


I am in perimenopause and had a hard time sleeping. I was hyper alert and couldn't sleep more than about four hours a night. I'd wake up and just stay awake with my heart racing and sweating.

Well, bioidentical estradiol cream 1 mg/day has helped me sleep much better and pretty much did away with the heart palpitations and night sweats. Estradiol also helped my memory. And I stopped snoring, which I had suddenly started to do when my ovaries begin to decline.

I titrated up from 0.01 mg, until I found a dose that helped. (The lower doses did absolutely nothing for me). I find I need to take it morning and night. The biggest problem for me is getting the estradiol to last all night. My body seems to use it up quickly. I wish all of you good luck. Please try to titrate for yourselves so that you can arrive at the right dose for you.


I'm so glad to have discovered these posts. I thought something was wrong. My doctor prescribed Estradiol 1mg, about a month ago. My feet and lower legs are regularly tingling, tight and swollen, and I've gained more weight in the past month than I've ever gained at one time! I'm moody, can't fit my clothes, and on and on! Thank you for your candid comments, ladies. I don't feel crazy anymore. I'd rather have hot flashes than all this. I'm done!


I have been on Estradiol 2 mg. tablets for about six weeks. The only problem I'm having is weight gain in my stomach. Does anyone else know how to keep this under control? It doesn't seem to matter what I eat. I've put on 10 pounds in six weeks.


Will hair grow back after stopping estradiol? I took 1mg. tabs. for six months. My hair was very thick when I started, but now is very thin. I also don't sleep well, and seem to worry more.


Oh wow! This hysterectomy is killing me! I have the estradiol patch, the lowest dose one and same symptoms, with my legs killing me, twitching pains, and the shooting chest pain scared me to death! I thought I was having a heart attack, and can barely walk due to my legs.

I'm seven weeks post op, and not sure what I'm going to do now. I've ripped off the patch! I don't even care if it's synthetic at this point but I have to do something. Yes, I'm on bio P too. I can't believe there aren't anymore doctors and research out there for this horrible and common world that's out there. God bless each of you!

I know it's pure hell. Unbelievable to me -- so many women, so sad. I too, felt like I'm losing it. Why aren't there more answers? Good luck!


I have been on estradiol, 1mg for 8 years and am attempting to quit cold turkey and was wondering if this is safe to do.


I just removed the Estradiol patch. I had serious issues. I did not have a doctor who had in depth training with bio identicals. I asked to up the patch strength after one month, which should have not been allowed. My progesterone remained the same and the side effects were horrible. My blood pressure spiked, my skin felt like it was going to stretch apart from the inside out, I had pains in my legs and felt like I was going crazy. My emotions were all over the place. Two days after the patch removal, I had a major emotional crash, but my heart rate has come down, although I still have pains in my legs. I also feel nauseated and have stomach pain and bad headaches. I'm praying that I will feel normal soon.

Others have had success. Make sure you are using a doctor experienced with Bio Identicals before you try. I will not use it again.



It seems that the majority of women here experience symptoms of estrogen deficiency while taking estradiol. The reason is because once you start taking it, the body's thirst for estrogen awakens and the body will keep asking for more for a while. If you have heart palpitations, low back pain, skin crawling, hot flashes, mental confusion and fog, inability to focus, all these are symptoms of estrogen deficiency. You have to look into different methods of delivery, not everyone absorbs well the creams or gels, for me the only thing that worked is applying that Bi-est cream intra-vaginally. No progesterone, progesterone makes me tired and confused and brain fogged.

My periods have stopped because of the estradiol, and it is normal. Every couple of months I switch to Estrogel which I absorb poorly, but it still keeps me somewhat leveled for a week and then I get my period. In other words, I need a higher level of estrogen to be able to function and a lower level to maintain my period. You guys need to read Dr. Vliet's book : "It's My Ovaries, Stupid!"


I'm 47 years old and I feel so frustrated. I went to my doctor for hot flashes and weight gain. The blood test showed I'm in menopause. I had a partial hysterectomy in 2007. He put me on estradiol this year (2013) and the mood swings were horrible.

I called him and told him I didn't like the way I felt on it and he said "that's fine, you don't have to take it" What the hell? Do these doctors want to help us? I'm up to 12 or more hot flashes per day and I'm miserable. My emotions are out of control and I just want to feel normal again.


I was diagnosed with premature ovarian failure (I'm 25) and have been on HRT using estradiol (EstroGel, 2.5mg daily) and progesterone for about two months now. Before HRT I was anxious to the point of vomiting, experiencing horrible hot flashes, very irregular periods, had very dry skin and couldn't sleep through the night. Since starting estradiol, I have felt immeasurably better. My hot flashes are gone, my mood has stabilized, my hair and skin are better (a bit of acne but that happened before), and I sleep much better.

The progesterone has been causing me issues. I started with Prometrium 200mg for 10 days. When I was on Prometrium I was back to being extremely anxious, crying very easily, and my hot flashes were back. I talked to my doctor and she's switched me to Provera, 2.5mg daily. I will be starting it tomorrow so hopefully it works out!


For IVF treatment, doctors put you on 6mg of estradiol per day. Can you imagine all these symptoms while you are looking forward to get pregnant? The anxiety and fatigue are the worst.


After taking estradiol 2 mg q day for four months, I quit cold turkey. With the withdrawal after approximately a week, I began to have slight vaginal bleeding. Is this normal with the sudden withdrawal.


Does estradiol stop the period due to birth control?


I have been taking estradiol low dose of .05. My legs hurt, I've been crying a lot and having night sweats, then yesterday I started bleeding a lot. I haven't had a period in 20 years. What is going on? I took off the patch and will not put it back on.


I actually take 6 mg a day. As a pharmacy technician, I am well aware of the side effects. I've been taking estradiol since January 2012, and have had no major problems (knock on wood) and have smoked off and on since.

When I started, I had night terrors for a little while, and I always have mood swings. I mean, it's hormones. That's going to happen. You just need to watch your blood pressure (especially if you smoke, and you should quit) and eat well. If you are overweight, you should make better efforts to lose the weight.

Yes you will cry easily. Yes you will be grouchy, but seriously, we're going to be like that either way so you might have to just deal with it. If you get a blood clot, obviously stop taking it and go to the ER.


I went to see my family physician yesterday. He prescribed Estradiol to deal with my hot flashes, and other symptoms related to menopause.

I read the posts above, and I am scared to go and pick it up and actually use it. Any of you can tell me at what dosage it has been prescribed?


I hear ringing and hissing in my ears too. I had awful reactions. Don't ever take this drug. It can also increase blood pressure and heart rate.


I am so glad I found this website. I thought I was going literally crazy! I'm having muscle and joint pain, night sweats, nightmares, and the mood swings still are bad. I am going back on Premarin.


There is a significant difference between "bio identical estradiol" and "bio identical progesterone," compared to synthetic. All the studies involve the synthetic, including premarin and provera.

On the contrary, the bio identical hormones are very safe, but must be prescribed by a physician and the levels should be kept in a normal range. Bio identical estradiol can prevent osteoporosis, heart disease, stroke and Alzheimer's and bio identical progesterone has been shown to prevent breast cancer by 20 percent, compared to women taking nothing after menopause.


I am so happy to find this site. I have all the same reactions. I could always eat and not worry.

I am 4'10" and used to weigh 97 pounds. Now I watch every bite I eat (not much). I weigh 108 and am still gaining.

I have headaches, my heart rate and blood pressure went way off the chart in the ER to a-fib. Now I am on coumadin (blood thinner), blood pressure meds and heart meds. My legs ache all the time.

I also was on premarin and doing very well. Yes, the insurance would not pay so, estradiol was prescribed. Terrible choice. I too will stop this medication. Thanks to all of you who really care and take the time and keep us informed.


I never knew estradial could cause all these symptoms. I've been on it for over a year now and I have chest pain, breathlessness and fatigue, nausea and joint pain. I've been begging the doctor to help me. Why hasn't he said this is due to the patch I keep applying?


Could Estradiol make my breasts larger? I have been on it for about three months and I have suddenly realized that that I have outgrown my C cup bras. I've only put on about five pounds since starting it.


I have been on the estrogen patch for four days now and I take natural progesterone cream daily. However, I took the patch off. Has anyone experienced bad dreams, well really, they're night terrors. Other than that, my back is hurting every day. I'm done with this.


Obviously, we are all experiencing the same symptoms and complaints from Estradiol. Why are they still prescribing this med? I have been on for three years since my total hysterectomy. I have gone on and off for the last year because I'm so tired of weight gain and other symptoms as described on this blog.

My doctor keeps sending me to the lab for blood work but nothing changes. She's only had me take double dose of Estradiol daily now for Osteoporosis. I'm sure the starting and stopping doesn't help the body but what does one do! I want to be back to my old self too!


I have been on estradiol for three months now, and my face has been breaking out like crazy. I have never had a breakout problem, but now they will not go away and are a little painful too. Has anyone else had this type of problem?


My girlfriend has started taking estradiol for a couple days now and well, I found this site looking for some kind of relief for her mood swings. She's having a lot of them and she doesn't notice, but everybody around her does.

She has been complaining of abdominal pain and she still has hot flashes. The doctor started her off with a 2 mg pill after her full hysterectomy.

Is there anything I can do to help her? After reading this, I'm starting to think that a 2mg pill is to much for her. She is only 30.


I was prescribed estradiol to stop bleeding after my mirena insertion. It has slowed, which is great, but I feel bizarre just after three days! I feel bloated, heart palpitations, anxiety, and have quick breathing. I am so irritable and not pleasant to be around at all. I am stopping this stuff today! I'm only 32 and not in menopause, but this stuff is definitely not for me.


Take estrogen and have an increased risk of heart attack, blood clots, endometrial cancer and breast cancer. No, this is not good. Well, is there some other kind of medicine or way to increase the level of estrogen. If some medication or treatment leads you toward an incurable disease, then never go for it.


You all are not imagining these issues. I too was switched to estradiol from premarin. I am going back on premarin. Thinning hair, legs hurt much more than normal, and the sweats don't stop. I used a blanket on premarin. What gives, doc?


The only reason I want to start using estradiol is because I have a burning tongue and eyes. I am 54, had a total hysterectomy 10 weeks ago.Started burning 5 weeks ago. I have been on premarin (vaginally)but hate the mess. After hearing all these comments, I do not know what to do. I need a miracle!


I have been using the estrogen patch for about three weeks and I have gained a ton of weight, have lower back pain and knee joint pain as well. I have already treated myself for a yeast infection and do not wish to get another one. I feel awful!

I took the patch off yesterday and am going to discontinue this med. I only hope I can take this weight off quickly! I am so bloated and nothing fits.


I am 65 have used three forms of Estrogen since my total hysterectomy in 1996. I used progesterone cream with all three forms of the estrogens. My labs must be monitored periodically. I have used estradiol, premarin, and now, Tri est in bioidentical cream with cycling bioidentical progesterone. I have educated myself about how to balance both.

It is a challenge to get labs two or three times a year and to adjust the hormone dosage based on the way you feel and not the same dosage each day. But I feel well, enjoy sex, and have only put on 10 pounds since the hysterectomy, which I think is fairly normal weight gain with a hysterectomy and aging.

Please find doctors who know what they are doing, educate yourselves about bioidentical estrogen and progesterone, know your lab levels of the hormones. Life is better after a hysterectomy if you are on the right hormones, educated and have balanced lab results.

I do not see many positive experiences posted. I wish each of you the best. It can be done but you have to work at it.

My hormones are not paid for by insurance but the labs are. Good luck and read, read, read, and get another doctor if you don't get better, and get those hormone levels checked.

You must use progesterone cream to balance estrogen in any form. Just because you do not have a uterus does not mean you don't need progesterone, and even a touch of testosterone to bring back the sex drive. Good luck.


I too am having bad effects with estradiol (elestrin topical). I am trying to wean off of it and it's horrible. I am not looking forward to the anxiety and mood swings that are coming when I start cutting the dose. I am trying today and am already shaky and have tremors. I'm better off with hot flashes.


I had a full hysterectomy eight months ago. I did not take any hormones just "natural" Estroven with black cohosh in it. It helped make the hot flashes not so bad for a while and then it just stopped helping at all and the hot flashes and restlessness were extreme.

I started taking Estradiol 1.0 a few months ago and I love it! No more hot flashes at all. I am sleeping through the night. My hair and skin look great and healthy. The down side is that I have put on weight, but I have joined a gym and will try to deal with the weight that way because the benefits of the Estradiol are greater and the weight I can work on. Good luck to you all.


If this medication is causing so many problems then why are people taking this medicine? Every medicine has some side effects and many benefits. Go for that medicine who have fewer side effects and problems.


to anon170668, post #32: What? You're 19 and in menopause and have been trying to get meds for nine years?. So you were 10 years old when you went into menopause. Don't be on this site telling legit people suffering terribly to stop complaining.


Whoever wrote this post thank you. You are helping so many women and men realize the truth about the evil of estradiol and estrogen dominance.

It would be nice if their were more honest people who actually cared about the effects this all too often idolized hormone from heck is. Thanks again and please keep up the work!


Has anyone here tried natural progesterone cream? I've been experiencing signs of estrogen dominance (had a hysterectomy three years ago, with one ovary removed). I am trying to wean off the estrogen patch and see what the progesterone can do for me.


I had one ovary and my uterus removed in 1990, with no HRT. My second ovary was removed at age 47 due to four abnormal looking tumors and severe adhesions.

I was put on Cenestin 1.25 mg. split in two and still had hot flashes. I put on ton of weight, etc. At $94 out of pocket, I switched to Estradiol 1 mg. for $4, one month ago. Awful, awful hot flashes still. Huge weight gain of 10 pounds in one month. Like clockwork, at 2 p.m., 10 am. and all night dripping wet with sweat pouring off of my neck and face. My hair is soaking wet even though it is 60 degrees in my home.

I stopped taking it cold turkey five days ago and for some reason the 2 p.m. and 10 a.m. severe hot flashes have waned a lot. I still have night hot flashes. Why would my hot flashes be better after stopping the drugs is beyond me. Now have to find a way to get this terrible weight off.

I am partially disabled due to four discs in my neck herniated but I need to find work and cannot go on interviews with these hot flashes coming out of the clear blue sky.

I also have high blood pressure and take 3 meds plus depression meds. Was told by bio-identical hormone dr. that if you have had both ovaries removed, bios won't work. She said that all glands, including the ovaries, have to be present for the bios to work. Help!


To all of you who has problems with estradiol, especially those who had a hystrectomy:

You can't take estradiol without taking bio-identical progesterone as well. No matter how small is the amount of E if it's unopposed by P, you will get the symptoms of estrogen dominance that all of you are describing. Both need to be taken cyclically as Nature intended, to replicate a healthy young woman's monthly cycle.

Find a doctor who is into bio-identical hormones, but avoid the Wiley protocol; it uses excessive amounts of hormones. And before you listen to anyone, educate yourself. Don't just believe doctors. Some of them are behind times and some don't have enough information on dosing, etc.


I started estradiol on Thursday and today is Sunday. I have already gained weight, have splitting headaches, and diarrhea and now have developed vertigo so severe I can't watch tv, lie down, walk straight or see! I've just taken the patch off and won't be trying any more! Good luck everybody.


I had a hysterectomy 26 years ago and was immediately put on Premarin with basically no side effects. Weight stayed steady, had no moodiness and life was good. However, I just started taking Estradiol two days ago because I'm on different insurance and Premarin is expensive.

If I start to feel like some of you after taking Estradiol, I won't wait long to get back on Premarin. I will go along with the old saying, "If it ain't broke, don't fix it", and hang the expense.


@anon164834 : The weight gain is most likely caused by the antidepressant. SSRIs and weight gain go hand and hand since seratonin is mostly found in the digestive system and meds that toy with that screw everything up down there.


you people need to stop complaining! I've been trying for nine years just to get medication. I'm 19 and in menopause!


I was wondering if Estradiol has anything to do with diarrhea. I have been on the 1 milligram pill for about three or four years now.I had a partial hysterectomy 36 years ago and was on Premarin and had no problems then. Just wondering if the Estradiol has anything to do with me having to go to the bathroom every time i eat.


I have been on estradiol for six years and I'm so sick of the yeast infection. it won't go away.


I have been on estradiol 1mg tablets since have a hysterectomy at the age of 37. I weighed 162-165lbs and stand 5'11" tall. I now weigh over 200lbs!

I've also been taking an antidepressant for anxiety. The estradiol seemed to work at first and I was sleeping but I've gone from a 14 in pants to an 18 and I've never been this big in my life except when I was pregnant with my son six years ago! I need to talk to my doctor about something else I can take.


i have had a hysterectomy done in 2009. ever since then i have been on estradiol and my experience has been very bad. i get depressed a lot and also have anxiety. when i stopped taking it i was feeling a lot better, but my gynecologist said i needed it. well i guess i have to live with those feelings.


I had a full hysterectomy December 2010 and started taking estradiol Dec a few days later. it is now February and I am having throbbing headaches, painful burning when urinating, round red spots on my legs that are growing bigger, at times not able to focus while reading,and sometimes depressed. I felt better with fibroids on my uterus and cysts on my ovaries than I do right now.


i have been taking estradiol for two months. My hair is brittle and coarse. It looks like it has been singed and has no manageability at all. Is this one of the side effects?


i just want to know can i just quit taking these estradiol cold turkey? I have calf pains,cramps, especially in the a.m. I have headaches, fogginess, depression, weight gain, tired all the time, aches all over just a miserable feeling, no sex drive, irritability. Horrible.


I had a complete hysterectomy in 1996 and went on Premarin. I have had no problems whatsoever. Then, three weeks ago, my OB/GYN switched me to Estradiol. For two weeks now, I have eperienced extreme nausea, low blood sugar levels, and extreme pain in my hip and legs. I quit the medication yesterday and already feel better. I am going back on my Premarin, even if it is "synthetic"!


I've been reading the side effects and seeing I'm not the only one. Almost all are exactly what I've been experiencing from taking the Estradiol (since my total hysterectomy this summer at the age of 47).

Seems my symptoms are getting worse. I can't sleep, have migraines and feel like I can't breathe without anything. Before the surgery I felt and was functioning fine with the exception of a huge mass that had to be removed. Was hardly ever sick.

Now, I feel like a different person: fatigued, arthritic, gaining so much weight, extremely forgetful. Never experienced anything like it. Isn't there anything else out there for those of us who have breast cancer that runs in the family? I want to feel normal again!


I have been on estradiol less than two months and the hot flashes have stopped! However, just like several others I am gaining a lot of weight, especially in the midsection and increased joint pain in knees and lower back. I had a hysterectomy this summer and both ovaries were removed. Which I am beginning to regret but oh well, that's done. I am coming off today!


In October, i had my ovaries removed and my doctor put me on estradiol and medroxyprogesterone and i have just been a mess ever since. I have had numbness in my legs and arms, can't sleep, weight gain w/terrible cravings, headaches, my whole body aches. I have spent so much on medical bills and still feel terrible. I feel like i've aged 10 years. And can't get back to normal and i'm sick of complaining about it!


I started to take estradiol as a hormone treatment. But in the beginning, i got a lot of headaches, but that is over. now I have some pain below my thorax, close to the xiphoid. Is is normal to have this side effect? also i have nausea too, and vomit.


I was on this for about three weeks and came off. Within a week I was a crazy woman, crying for no reason, throbbing headache, foggy brain. it was awful. I thought I was losing my mind. After a full week of this weird withdrawal I was back to normal. I would never ever take this med again.


I have been taking Estradoil for three years now. I had a complete hysteroctomy/overies and all. The only problem I have is weight gain. I was a nice 130 lbs, now I'm 155 lbs. I am 54 years old, 5'3 tall. How do I get rid of the weight?


i started taking estradiol about one month ago. i feel sleepy all the time. i have headaches and my body aches all over, mostly in my legs. I also have pain in my chest and itchy skin. So now my doctor upped my dose. he thinks it needs to be increased. We'll see. before this medication i was an energetic person who could wrestle a bear. Now he can walk all over me.


I have been on estradiol for five years now and i have very bad pain in my arm. Heart problems now I'm taking pills to slow my heart rate down. yeast infections that are mild but won't go away. I don't remember things like i use to. i have gained weight and i have no desire for sex at all. I have had both ovaries removed so i have to take the pills. Is there anything else i can take?


I was on Estradiol for 39 days. I have had severe pain in my legs, calves and body. I've had to take six pain pills daily. I've been off of it for 14 days. I'm better but still not back to normal.

I have no idea why I *still* feel like this after being off for 14 days. I've finished my chemo and went through a hysterectomy but feel worse than ever due to this medicine!


I took estrogen in pill form briefly after hysterectomy and had a severe downward mood shift with fatigue, etc. (Had a similar reaction to birth control pills years earlier and had to quit.) I switched to an estrogen patch and had no problems whatsoever! Stayed on the patch for 14 years.


I've been taking Estradiol for only two weeks and I have numbness in my legs and feet. I also have been experiencing weakness and severe pain in my legs. My legs have these huge masses that are not going away. The doctor has me coming in for tests so I would recommend that nobody should take this medication. It's sue time.


I have been taking estradiol only for two months and I have gained serious water weight and have sharp pains in my chest. I am going to stop taking this medication. I was feeling better before taking estradiol. I would rather deal with the hot flashes.


I have been on estradiol for five years and I have been having heart palpitations, decreased sex drive, pain in my breast and swelling. I had some concerns about long term use of HRT. I will definitely quit taking estradiol after reading this article.


i have been on this drug for many years. it helps with sleeping and hot flashes. i have dementia tendencies (or do i have dementia) and my thyroid problems have increased and i have hair loss. i am 60 and after reading this, I'm stopping the drug myself!


Since I have been on Microgestin, which is an estradiol birth control pill, I have had recurring yeast infections. What other birth control pill ingredient options do I have?


My veins have started itching and seem swollen, and my head feels heavy. this is after four days on estardot 25. is this normal at first? thanks.


Ever since my implant (that can not be reversed) I have the most awful skin crawling/itching, especially at night and have not had a decent night's sleep in five weeks. My nipples have become enlarged and very tender as well as the genital area. I am also extremely irritable and anxious which is not in my nature at all.


Ever since I have taken estradiol I have problems with my heart, sometimes difficulty in walking, bad sleep, and crying easily. Are there any connections among estradiol and my symptoms? Thanks, CWM


could estradiol make me cry easily?


could estradiol cause ringing or hissing in my ears?

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    • Side effects of estradiol may include heartburn.
      By: kmiragaya
      Side effects of estradiol may include heartburn.
    • Women who use estradiol may notice breast growth and tenderness.
      By: Connor Evans
      Women who use estradiol may notice breast growth and tenderness.
    • Nausea and stomach pain are common side effects of estradiol.
      By: lusielia
      Nausea and stomach pain are common side effects of estradiol.
    • Side effects of estradiol may include hair loss.
      By: Barabas Attila
      Side effects of estradiol may include hair loss.
    • Headaches are a common side effect of estradiol.
      By: Subbotina Anna
      Headaches are a common side effect of estradiol.
    • Breast tenderness is a common side effect of estradiol.
      By: Arto
      Breast tenderness is a common side effect of estradiol.
    • Estradiol should be used for the shortest possible time period.
      By: Monkey Business
      Estradiol should be used for the shortest possible time period.