We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

What are the Pros and Cons of Promethazine Codeine?

By Lee Johnson
Updated: Mar 03, 2024

Promethazine codeine is a syrup-based medication that contains promethazine, an antihistamine, and codeine, an opioid analgesic and cough suppressant. The pros of the treatment are that it can be used to treat runny nose, sneezing, pain, coughing, and itchy eyes, nose, and throat. The negative effects of using promethazine codeine are side effects such as blurred vision, dizziness, constipation, nausea, vomiting, and tiredness or weakness. There is also a small risk of addiction, because the drug contains the opioid drug codeine. Promethazine codeine can be fatal to children under 6 years old.

The promethazine codeine combination is generally efficient in reducing symptoms commonly associated with allergic reactions, such as runny nose, sinus drainage, and itching of the eyes, nose, and throat. This is a result of the promethazine, which is an antihistamine drug that is generally used for the treatment of allergies. Codeine is an opioid drug (of the same family as opium and heroin) that is a pain reliever and cough suppressant. The drug works by reducing the cough reflex in the brain.

Promethazine codeine should not be taken by anyone currently taking any other opioid-related medicines such as oxycodone, or any phenothiazines such as chlorpromazine. The drug also should not be taken by anyone experiencing any breathing difficulties, severe drowsiness, or a fever and a productive cough. Additionally, the drug should be avoided by anyone currently taking sodium oxybate.

There are also several factors in a patient’s medical history that may cause promethazine codeine to have an adverse effect. These include but are not limited to heart problems, low blood pressure, seizures, liver or kidney problems, enlarged prostate, bladder problems, stomach or bowel problems, or a history of substance abuse. There is also a risk of interaction with drugs such as haloperidol, naltrexone, and levodopa.

The side effects associated with promethazine codeine include blurred vision, constipation, dizziness, drowsiness, nausea or vomiting, headache, tiredness or weakness, and dry mouth, throat, or nose. These are common side effects associated with the drug, and are not cause for medical attention unless they are particularly severe or persistent. The less common side effects associated with promethazine codeine include allergic reactions, agitation, abnormal thoughts, confusion, fainting, loss of coordination, hallucinations, mood changes, lightheadedness, tremors, and yellowing of the skin or eyes. These less common side effects are considered severe, and should be brought up to a doctor as soon as possible.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
By anon250567 — On Feb 26, 2012

I was prescribed this cough syrup, and took the normal dosage. The abnormal thoughts are weird, and happened the next night as well. I didn't use it afterward.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.