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What are the Pros and Cons of Promethazine Codeine?

Promethazine codeine, a potent cough suppressant, can effectively ease symptoms but carries risks such as drowsiness and dependency. Its misuse can lead to severe health issues. It's crucial to weigh its benefits against potential dangers under medical guidance. Have you considered how this medication might impact your health in the long term? Join the conversation to learn more.
Lee Johnson
Lee Johnson

Promethazine codeine is a syrup-based medication that contains promethazine, an antihistamine, and codeine, an opioid analgesic and cough suppressant. The pros of the treatment are that it can be used to treat runny nose, sneezing, pain, coughing, and itchy eyes, nose, and throat. The negative effects of using promethazine codeine are side effects such as blurred vision, dizziness, constipation, nausea, vomiting, and tiredness or weakness. There is also a small risk of addiction, because the drug contains the opioid drug codeine. Promethazine codeine can be fatal to children under 6 years old.

The promethazine codeine combination is generally efficient in reducing symptoms commonly associated with allergic reactions, such as runny nose, sinus drainage, and itching of the eyes, nose, and throat. This is a result of the promethazine, which is an antihistamine drug that is generally used for the treatment of allergies. Codeine is an opioid drug (of the same family as opium and heroin) that is a pain reliever and cough suppressant. The drug works by reducing the cough reflex in the brain.

Promethazine codeine can be used as a cough suppressant.
Promethazine codeine can be used as a cough suppressant.

Promethazine codeine should not be taken by anyone currently taking any other opioid-related medicines such as oxycodone, or any phenothiazines such as chlorpromazine. The drug also should not be taken by anyone experiencing any breathing difficulties, severe drowsiness, or a fever and a productive cough. Additionally, the drug should be avoided by anyone currently taking sodium oxybate.

Children under the age of six should not be prescribed cough syrup that contains promethazine.
Children under the age of six should not be prescribed cough syrup that contains promethazine.

There are also several factors in a patient’s medical history that may cause promethazine codeine to have an adverse effect. These include but are not limited to heart problems, low blood pressure, seizures, liver or kidney problems, enlarged prostate, bladder problems, stomach or bowel problems, or a history of substance abuse. There is also a risk of interaction with drugs such as haloperidol, naltrexone, and levodopa.

Promethazine codeine may be used to treat a runny nose.
Promethazine codeine may be used to treat a runny nose.

The side effects associated with promethazine codeine include blurred vision, constipation, dizziness, drowsiness, nausea or vomiting, headache, tiredness or weakness, and dry mouth, throat, or nose. These are common side effects associated with the drug, and are not cause for medical attention unless they are particularly severe or persistent. The less common side effects associated with promethazine codeine include allergic reactions, agitation, abnormal thoughts, confusion, fainting, loss of coordination, hallucinations, mood changes, lightheadedness, tremors, and yellowing of the skin or eyes. These less common side effects are considered severe, and should be brought up to a doctor as soon as possible.

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Discussion Comments

anon250567

I was prescribed this cough syrup, and took the normal dosage. The abnormal thoughts are weird, and happened the next night as well. I didn't use it afterward.

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    • Promethazine codeine can be used as a cough suppressant.
      By: ramonespelt
      Promethazine codeine can be used as a cough suppressant.
    • Children under the age of six should not be prescribed cough syrup that contains promethazine.
      By: JPC-PROD
      Children under the age of six should not be prescribed cough syrup that contains promethazine.
    • Promethazine codeine may be used to treat a runny nose.
      By: Graça Victoria
      Promethazine codeine may be used to treat a runny nose.