We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Factors Affect the Secretion of Antidiuretic Hormone?

By Greg Caramenico
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

The secretion of antidiuretic hormone (ADH), also called vasopressin, occurs in the pituitary gland of the brain and keeps water in the bloodstream. The main factors affecting its release are a reduction in the amount of water in the plasma and an increase in the number of solid molecules, like sugar and salt, in the bloodstream. ADH works partly by causing the kidneys to reabsorb water rather than to excrete it as urine. When this process is impaired, diabetes insipidus results.

Vasopressin is a peptide hormone that regulates the reabsorption of water and salts in humans and other mammals. In the kidneys, it controls changes in the permeability of the tubules in order to prevent the excretion of salts and glucose. The manufacture and secretion of antidiuretic hormone occurs in the posterior pituitary gland of the brain, where it is one of only two hormones released, the other being oxytocin. ADH is secreted whenever the body becomes hypovolemic from significant fluid loss.

When a decrease in blood plasma osmolarity, a marker of water loss, is detected by receptors in the blood vessels, they send signals to the brainstem's medulla. Here nerves relay the information to the hypothalamus, which controls pituitary secretion of hormones. Receptors for angiotensin are located on the hypothalamus, so this hormone also can increase vasopressin secretion. Blood pressure drops that get detected by arterial stretch receptors cause ADH release too. The brain centers that respond to blood pressure and osmolarity are the ones modulating vomiting and nausea, both of which increase vasopressin release in a complex feedback loop.

The prevention of water excretion in urine is the main function of vasopressin. This is why ingesting diuretics causes compensatory secretion of antidiuretic hormone. When activated by vasopressin, the collecting ducts of the kidneys open water channels that reabsorb water, which otherwise gets expelled as urine. If ADH does not reach these channels and bind to the receptors that control them, more water is lost. Alcohol consumption can reduce the effects of the hormone and cause water loss and dehydration, since ethanol binds to ADH receptors in the collecting ducts, blocking the hormone's actions.

Diabetes insipidus results from problems with the secretion of antidiuretic hormone. Central diabetes is caused when the hypothalamus, injured by trauma or pressured by a tumor, stops producing the chemicals that tell the pituitary to make ADH. This can usually be treated by giving the patient supplemental vasopressin. Diabetes insipidus also results when the receptors in the collecting ducts of the kidneys do not respond to antidiuretic hormone, and the water channels remain closed. Patients with diabetes insipidus produce great quantities of urine as a result of their condition, and experience increasing thirst as a result.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

By cookiedough — On Mar 06, 2014

So a lack of ADH or lack of reaction to ADH is what causes diabetics to feel so thirsty and urinate so much.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.