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What are Catecholamines?

Catecholamines are vital chemical messengers in your body, including adrenaline and dopamine, orchestrating your fight-or-flight response and influencing your mood. These powerful compounds help regulate heart rate, blood pressure, and energy use. Intrigued by how these substances impact your daily life? Discover their profound effects on your well-being as we delve deeper into the world of catecholamines. Ready to learn more?
Karyn Maier
Karyn Maier
Karyn Maier
Karyn Maier

Catecholamines are water-soluble chemical compounds that are synthesized in the body from the amino acid tyrosine. They are classified as adrenal hormones and, as such, are produced and released into the bloodstream in response to the stimulation of the preganglionic sympathetic nerves of the adrenal medulla. This event occurs in times of stress, whether due to emotional trauma, physical exertion, pain, or excitement. However, catecholamines production may also be triggered by low blood sugar. The predominantly occurring hormones are dopamine, norepinephrine, and epinephrine (formerly known as adrenaline).

As might be expected, there are certain biological reactions that accompany a copious release of catecholamines. While dopamine is one of the “feel good” hormones that promote a sense of euphoria, norepinephrine and epinephrine produce a very different experience since they act on the central nervous system and increase heart rate and blood pressure. In fact, these types of catecholamines are responsible for initiating the “fight or flight” response. However, it is interesting to note that norepinephrine and epinephrine are both synthesized as byproducts of dopamine production.

Dried vanilla beans. Vanilla can raise catecholamine levels.
Dried vanilla beans. Vanilla can raise catecholamine levels.

Abnormally elevated levels of circulating catecholamines may indicate toxicity and the presence of a medical disorder. For example, unusually high levels may be due to a deficiency of monoamine oxidase A, the agent that naturally degrades these hormones within minutes of release. High levels may also be associated with several rare disorders, such as ganglioneuroma and neuroblastoma. A chromaffin cell tumor affecting the adrenal glands can lead to a hypertensive disorder known as pheochromocytoma. In addition, numerous medications can increase catecholamine production, including nitroglycerin, levodopa, tetracycline, lithium, insulin, and caffeine.

Numerous medications can increase catecholamine production in the body.
Numerous medications can increase catecholamine production in the body.

If an adrenal hormone-related disorder is suspected, blood and urine tests may be performed, although urine samples usually provide more accurate readings. Measurements of catecholamines are given a value of nanograms per milliliter and are expressed as ng/100 mL. What is considered normal may vary between individuals and even testing facilities. Generally speaking, however, a normal level of norepinephrine is considered to be 60 ng/100 mL and epinephrine 20 ng/100 mL.

Coffee and other sources of caffeine increase the body's levels of cathecholamines.
Coffee and other sources of caffeine increase the body's levels of cathecholamines.

Patients are often advised to do everything possible to avoid emotionally charged or physically stressful situations prior to testing since these scenarios could impact catecholamine production. Certain foods should also be avoided for several days before testing. For example, caffeine-laden beverages, citrus fruits, bananas, chocolate, and vanilla all raise catecholamine levels. However, the patient should not cease taking any medication without consulting a physician, even if it is known to increase production of these adrenal hormones.

Catecholamines may be released by the body during times of stress.
Catecholamines may be released by the body during times of stress.

If catecholamine levels are found to be elevated, treatment is available. Generally, therapy is in the form of agents that suppress alpha or beta adrenoceptors located in smooth muscle tissue. These antagonists are commonly known as alpha-blockers and beta-blockers.

Karyn Maier
Karyn Maier

Contributing articles to TheHealthBoard is just one of Karyn’s many professional endeavors. She is also a magazine writer and columnist, mainly for health-related publications, as well as the author of four books. Karyn lives in New York’s Catskill Mountain region and specializes in topics about green living and botanical medicine.

Learn more...
Karyn Maier
Karyn Maier

Contributing articles to TheHealthBoard is just one of Karyn’s many professional endeavors. She is also a magazine writer and columnist, mainly for health-related publications, as well as the author of four books. Karyn lives in New York’s Catskill Mountain region and specializes in topics about green living and botanical medicine.

Learn more...

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Discussion Comments

Nefertini

@Ceptorbi - Catecholamine effects made me have to reduce my coffee intake. I developed a rapid heartbeat from drinking too much coffee. Lowering my caffeine consumption brought it back to normal.

Ceptorbi

With a pheochromocytoma tumor in the adrenal glands, there can be a catecholamines hypertension link in that the excess production of catecholamines due to the tumor results in high blood pressure.

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    • Dried vanilla beans. Vanilla can raise catecholamine levels.
      By: Picture Partners
      Dried vanilla beans. Vanilla can raise catecholamine levels.
    • Numerous medications can increase catecholamine production in the body.
      By: robert lerich
      Numerous medications can increase catecholamine production in the body.
    • Coffee and other sources of caffeine increase the body's levels of cathecholamines.
      By: volff
      Coffee and other sources of caffeine increase the body's levels of cathecholamines.
    • Catecholamines may be released by the body during times of stress.
      By: bukovski
      Catecholamines may be released by the body during times of stress.
    • Urine samples may be collected to determine the reasoning behind abnormally elevated levels of catecholamines.
      By: Tootles
      Urine samples may be collected to determine the reasoning behind abnormally elevated levels of catecholamines.
    • Those who have a condition that limits their ability to convert dopamine from tyrosine may have a difficult time remaining alert enough for every day activities.
      By: Halfpoint
      Those who have a condition that limits their ability to convert dopamine from tyrosine may have a difficult time remaining alert enough for every day activities.
    • A chromaffin cell tumor affecting the adrenal glands may cause pheochromocytoma.
      By: maya2008
      A chromaffin cell tumor affecting the adrenal glands may cause pheochromocytoma.
    • Abnormally elevated levels f circulating catecholamines may indicate toxicity and lead to the development of memory problems.
      By: mocker_bat
      Abnormally elevated levels f circulating catecholamines may indicate toxicity and lead to the development of memory problems.