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What Is the Difference between ARBs and ACE Inhibitors?

ARBs (Angiotensin II Receptor Blockers) and ACE Inhibitors (Angiotensin-Converting Enzyme Inhibitors) both lower blood pressure by targeting the renin-angiotensin system, but they work differently. ARBs block receptors for angiotensin II, a potent blood vessel constrictor, while ACE inhibitors prevent the formation of angiotensin II itself. Curious about which might be better for you? Let's explore their unique benefits and uses.
Tricia Christensen
Tricia Christensen
Tricia Christensen
Tricia Christensen

Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors differ the most in the way that they affect the renin-angiotensin-aldosterone (RAA) system, which helps to control blood pressure. Other slight differences between ARBs and ACE inhibitors can include a decreased risk of certain side effects, especially persistent cough with ARBs. Some studies have suggested that women who use ARBs after a heart attack have higher survival rates than women who use ACE inhibitors. In most other ways, these two classes of drugs are very similar.

ARBs and ACE inhibitors affect the RAA system in slightly different ways that both relate to angiotensin II. This is a powerful chemical that signals blood vessels to constrict, and it can contribute to hypertension. ARBs, such as candesartan, losartan, and irbesartan, prevent angiotensin II from connecting with receptors on small arteries. This means that the blood vessels don’t narrow, and blood pressure is reduced.

ACE inhibitor capsules.
ACE inhibitor capsules.

The action of ACE inhibitors is very different, though the overall effect is similar. Medications like benzapril, enalapril, and lisinopril prevent the conversion of angiotensin I into angiotensin II. The absence of this chemical means the blood vessels get few chemical messages to constrict, and blood pressure normalizes.

Another difference between the two may be the degree to which certain side effects are experienced. Patients who have trouble tolerating ACE inhibitors are often switched to an ARB. This is mainly due to the symptoms of difficult coughing that ACE inhibitors commonly cause. An ARB can have this side effect, too, but not as often, and many patients are made more comfortable if they switch to one.

ARBs and ACE inhibitors operate in different ways to reduce blood pressure.
ARBs and ACE inhibitors operate in different ways to reduce blood pressure.

Moreover, preliminary research suggests that ARBs may be a better choice for women who have experienced a heart attack. Some studies have evaluated mortality rates in women who take these medications after a heart attack. The evidence suggests that ARBs appear to improve life expectancy, but only for women. There needs to be more study in this area to confirm these results.

ACE inhibitors may cause some patients to develop a persistent cough.
ACE inhibitors may cause some patients to develop a persistent cough.

Despite some differences, ARBs and ACE inhibitors are similar in many ways. They’re both recommended to regulate high blood pressure, lengthen survival after a heart attack, and slow the progression of kidney failure caused by diabetes. Drugs from these classes may additionally protect against stroke. It's also suggested that these medications may help prevent high cholesterol.

ARBs may be a better choice for women who have had a heart attack.
ARBs may be a better choice for women who have had a heart attack.

These drugs also have comparable side effects, including headache, dizziness, and cough. Additional adverse reactions include diarrhea, rash, and allergy. Both classes of drugs can cause serious birth defects and may interact with the same medications, like lithium.

Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent TheHealthBoard contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

Learn more...
Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent TheHealthBoard contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

Learn more...

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    • ACE inhibitor capsules.
      By: Sergey Lavrentev
      ACE inhibitor capsules.
    • ARBs and ACE inhibitors operate in different ways to reduce blood pressure.
      By: niyazz
      ARBs and ACE inhibitors operate in different ways to reduce blood pressure.
    • ACE inhibitors may cause some patients to develop a persistent cough.
      By: Photographee.eu
      ACE inhibitors may cause some patients to develop a persistent cough.
    • ARBs may be a better choice for women who have had a heart attack.
      By: 9nong
      ARBs may be a better choice for women who have had a heart attack.