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What Is the Difference between Lisinopril and Amlodipine?

By Jacquelyn Gilchrist
Updated: Mar 03, 2024

Lisinopril and amlodipine are both medications that may be used to lower high blood pressure, but they are different types of drugs. As a calcium channel blocker, amlodipine relaxes blood vessels and accelerate the flow of blood to the heart. It may also help prevent chest pain, but it cannot treat chest pain that has already started. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, which means that it interferes with chemicals in the body that tighten the blood vessels. This allows for more efficient blood circulation, and the drug may also boost the chances of survival following a heart attack.

Both of these high blood pressure medications are taken orally, usually once daily. The doctor may prescribe a lower dose initially, to be increased gradually as needed. Those taking lisinopril may need to undergo periodic kidney and liver function tests. When they are used to treat high blood pressure, these medications are intended to be part of a comprehensive treatment plan that should include a healthy diet and regular exercise.

Certain precautions should be followed while using these medications. Both lisinopril and amlodipine may interact with alcohol and cause extremely low blood pressure, which can raise the risk of some side effects. Those taking lisinopril should avoid using potassium supplements or salt substitutes unless otherwise directed by a physician.

Lisinopril and amlodipine may cause some side effects, which should be reported to the prescribing physician if they become severe. They may cause dizziness, drowsiness, and headache. Lisinopril may also cause nausea, vomiting, and depression, while amlodipine may cause fatigue and flushing.

More serious side effects require urgent medical care. These drugs may both cause swelling, feeling faint, and chest pain. Those taking lisinopril should monitor themselves for unusual, rapid weight gain, unusually low amounts of urine output, and flu symptoms. Amlodipine may cause pounding heartbeats, malaise, and a heavy, painful sensation that spreads to the arm or shoulder.

Before using lisinopril and amlodipine, patients must disclose their other medical conditions, medications, and supplements. Lisinopril can cause birth defects and should never be used by women who are pregnant, while it is unknown if amlodipine will harm a fetus. It is also unknown whether either of these drugs may pass into breast milk. These drugs may be contraindicated for use by those with kidney or liver disease, diabetes, and a heart valve problem. Other medicines may interact with lisinopril and amlodipine, including beta-blockers, diuretics, and aspirin.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
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Discussion Comments
By fBoyle — On Feb 28, 2013

I've been on both of these medications and from my personal experience, amlodipine is better. I don't mean that lisinopril isn't effective, it is. Both of these reduced my blood pressure like they were supposed to but I experienced a lot of side effects from lisinopril.

Lisinopril gave me a chronic cough and I was always tired. A few times, I got very dizzy from it as well. I still feel a little tired with amlodipine, but not as much and I don't have the other side effects at all.

By discographer — On Feb 27, 2013

@fify-- These drugs work in different ways but since they both affect blood pressure, they have a commonality and that is they should never be stopped abruptly.

I have a relative who was taking a medication for high blood pressure and forgot to take it one day. He was taken to the emergency room that day because of irregular heartbeat and risk of stroke.

The body gets used to these drugs and if the patient has to stop them, they have to do it slowly and under the supervision of a doctor.

By fify — On Feb 27, 2013

Is withdrawal from one of these drugs easier than the other?

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