We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Are the Pharmacokinetics of Diclofenac?

By Maggie J. Hall
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

The pharmacokinetics of diclofenac describes the absorption, metabolism, and excretion processes occurring in the body after the drug is administered. Relevant information includes whether or not patients take the medication with food and the biotransformation the substance undergoes as part of the metabolic process. The kidneys and liver generally eliminate substances from the body, and data on the pharmacokinetics of diclofenac provides details as to which organ assumes primary responsibility for excretion and what medical conditions may hinder the process.

The rate at which the drug is absorbed following it's administration is one aspect of pharmacokinetics of diclofenac. The rate differs depending on whether a patient receives the drug by intravenous administration, intramuscular injection, or oral tablet form, and medication levels typically increase the fastest following intravenous administration. Physicians suggest taking the oral form of the medication with food. Although this action slows the absorption process, it minimizes gastric distress while still allowing the body to fully absorbs the medication.

Once absorbed, the body metabolizes, or breaks down the compound into metabolites and conjugates. These substances generally bind to proteins, particularly albumin. The pharmacokinetics of diclofenac includes the distribution of the drug, in which the proteins carry the medication through the blood and into various bodily tissues. Through a diffusion process, diclofenac enters tissues that contain little to none of the drug. When tissue levels of the medication exceed levels in the bloodstream or the extracellular spaces, proteins carry the medication out of the tissues.

The pharmacokinetics of diclofenac also include excretion. The kidneys eliminate two-thirds of the medication from the body while the other third binds with bile and leaves the body through the bowels. Patients diagnosed with renal malfunction cannot effectively excrete the medication, which can lead to renal toxicity. Patients with heart, kidney, or liver impairment may require dose adjustments or a reduction in the treatment time frame. Patients who take diuretics or angiotenson converting enzyme (ACE) inhibitors may also experience adverse effects.

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) group. Pharmacists classify it as a cyclo-oxyenase (COX) inhibitor that primarily deals with the COX 1 and COX 2 prostaglandins. Its uses include relief of pain, inflammation, and fever. Physicians prescribe the medication for mild to moderate pain, including pain caused by osteoarthritis and traumatic injury. Women might take the compound for the relief of painful menstruation.

Aspirin, cyclosporine, and methotrexate may interact with diclofenac as it inhibits or potentiates the effects of these and other medications. Studies indicate that patients taking the substance may be at greater risk for developing blood clots, leading to heart attacks or strokes. Patients taking diclofenac are also typically more likely to experience gastrointestinal ulceration and bleeding.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.