We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Papillary Renal Cell Carcinoma?

Mary Elizabeth
By
Updated Mar 03, 2024
Our promise to you
The Health Board is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At The Health Board, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Papillary renal cell carcinoma is one of the types of renal cell cancer, also known as renal adenocarcinoma or kidney cancer. Renal cell cancers are malignant cells found in the lining of kidney tubules, the purpose of which is to clean the blood. Tumors of the kidney may be any of five basic cell types: clear-cell; chromophilic-cell, chromophobic-cell, oncocytic-cell, or collector duct cell type. The second of these—chromophilic-cell—is also referred to as papillary renal cell carcinoma, or PRCC.

Carcinoma refers to a malignant cancer that stems from cells in epithelial, or lining, tissue of the body. Papillary refers to small protuberances like those on the top of the tongue, also described as “finger-like,” that are characteristic in this tumor. And chromophilic because of the way the cells of the papillary renal cell carcinoma react to dyes used to make them visible under the microscope.

Renal cell carcinomas only represent three percent of malignancies in adults, and instances of papillary renal cell carcinoma make up around ten to fifteen percent of renal cell tumors. It is the second most common subtype of renal cell carcinoma, after clear cell renal cell carcinoma, abbreviated RCC. It is estimated that five times as many males as females get papillary renal cell carcinoma.

There is a hereditary form of this carcinoma called hereditary papillary renal carcinoma which is caused by chromosomal translocation. This genetic form of the disease results in multiple tumors forming in both kidneys. While similar to von Hippel-Lindau syndrome and Birt-Hogg-Dube syndrome in being hereditary, it is a distinct disease.

Besides heredity, there are some more general risk factors for renal cell carcinoma, including male gender, being African American, being over 60; smoking cigarettes, obesity, having high blood pressure, and a high calorie diet. Occupational exposure to chemicals and substances, including asbestos and cadmium, can also increase risk. In addition, medical treatments, such as dialysis, and certain medications, including pain killers and diuretics, can increase a person’s risk of getting a renal cell carcinoma.

Symptoms of papillary renal cell carcinoma can include anemia, bloody urine, brown or red urine, feelings of lethargy or malaise, fever, lower back pain, nausea, vomiting, and weight loss. Depending on the stage of the cancer when it is diagnosed, treatment options include biologic therapy, chemotherapy, radiation therapy, surgery, stem cell transplant, and targeted therapy.

The Health Board is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Mary Elizabeth
By Mary Elizabeth
Passionate about reading, writing, and research, Mary Elizabeth is dedicated to correcting misinformation on the Internet. In addition to writing articles on art, literature, and music for The Health Board, Mary works as a teacher, composer, and author who has written books, study guides, and teaching materials. Mary has also created music composition content for Sibelius Software. She earned her B.A. from University of Chicago's writing program and an M.A. from the University of Vermont.
Discussion Comments
Mary Elizabeth
Mary Elizabeth
Passionate about reading, writing, and research, Mary Elizabeth is dedicated to correcting misinformation on the...
Learn more
The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.

The Health Board, in your inbox

Our latest articles, guides, and more, delivered daily.