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What is Prerenal Azotemia?

Prerenal azotemia is a kidney condition where blood flow to these vital organs is reduced, leading to a buildup of nitrogenous waste in the blood. It's often reversible with prompt treatment. Intriguingly, the causes and symptoms are varied, affecting individuals differently. How does this condition manifest, and what steps can one take to prevent or manage it? Join us as we uncover the intricacies of prerenal azotemia.
Emma Lloyd
Emma Lloyd

People with prerenal azotemia have an abnormally high level of nitrogenous wastes such as urea and creatinine in their blood. These types of waste are potentially toxic when present in the blood in large quantities, so this condition can be serious. Prerenal azotemia is a common blood disorder in people who have been hospitalized as a result of kidney failure or conditions that affect blood flow to the kidneys such as burns, dehydration, hemorrhage and chronic diarrhea or vomiting.

Along with the liver, the kidneys are instrumental in filtering the blood and removing potentially harmful substances. If blood flow to the kidneys is reduced, the ability of the kidneys to filter the blood also is impaired. Waste and toxins that normally would be removed remain in the blood, and urine output is severely reduced, leading to abnormal fluid retention. When blood levels of urea and creatinine are abnormally high, as in prerenal azotemia, these toxic substances can impair organ function and damage tissues.

If the cause of prerenal azotemia is blood or fluid loss, treatment might involve a transfusion of blood.
If the cause of prerenal azotemia is blood or fluid loss, treatment might involve a transfusion of blood.

Common symptoms of azotemia include reduced alertness, confusion, fatigue and thirst. People with this condition also are likely to have reduced urine output, a dry mouth, pale skin, swelling caused by fluid retention, increased night-time urination and a rapid pulse. Other possible symptoms include abdominal pain, low blood pressure, dry mucous membranes and reduced skin elasticity.

Confusion is a common symptom of azotemia.
Confusion is a common symptom of azotemia.

This condition generally is diagnosed on the basis of blood tests for creatinine and urea as well as tests to check creatinine and sodium levels in the urine. In addition, kidney function tests and blood osmality tests might be carried out. The blood osmality test checks the concentration of all particles in the blood and is carried out to evaluate the body’s fluid balance, which is affected by hydration levels and kidney function.

People with prerenal azotemia may exhibit unusual fatigue and a rapid pulse rate.
People with prerenal azotemia may exhibit unusual fatigue and a rapid pulse rate.

The main objective in treating prerenal azotemia is to correct the cause of the imbalance as quickly as possible in order to prevent permanent kidney damage. Treatment often includes one or more sessions of dialysis to reduce the toxin load in the blood. If the cause of the condition is blood or fluid loss, treatment might involve a transfusion of blood or blood products or the administration of other intravenous fluids to restore blood volume and improve the balance of nitrogenous wastes in the blood.

Treatment of pre-renal azotemia could include one or more sessions of dialysis to reduce the toxin load in the blood.
Treatment of pre-renal azotemia could include one or more sessions of dialysis to reduce the toxin load in the blood.

When the cause of azotemia can be treated quickly and successfully, the condition can be reversed and permanent kidney damage prevented. For treatment to be successful, however, it typically must be administered within 24 hours of the first signs of azotemia occurring. Prerenal azotemia can be complicated by acute renal failure or acute tubular necrosis. This latter condition occurs when kidney tissue begins to die off, so it therefore is associated with permanent and irreversible kidney damage.

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    • If the cause of prerenal azotemia is blood or fluid loss, treatment might involve a transfusion of blood.
      By: Pavle
      If the cause of prerenal azotemia is blood or fluid loss, treatment might involve a transfusion of blood.
    • Confusion is a common symptom of azotemia.
      By: chuugo
      Confusion is a common symptom of azotemia.
    • People with prerenal azotemia may exhibit unusual fatigue and a rapid pulse rate.
      By: Alliance
      People with prerenal azotemia may exhibit unusual fatigue and a rapid pulse rate.
    • Treatment of pre-renal azotemia could include one or more sessions of dialysis to reduce the toxin load in the blood.
      By: Tyler Olson
      Treatment of pre-renal azotemia could include one or more sessions of dialysis to reduce the toxin load in the blood.